Wu Na, Shi Wenming, Sun Xinghuai
Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
NHC Key Laboratory of Myopia (Fudan University), Key Laboratory of Myopia, Chinese Academy of Medical Sciences, and Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai, China.
Transl Vis Sci Technol. 2024 Mar 1;13(3):7. doi: 10.1167/tvst.13.3.7.
The purpose of this study was to investigate the association between long-term exposure to ambient air pollutants and the risk of acute primary angle closure (APAC).
Two hundred eighty-one (281) patients with APAC and 730 age- and sex-matched controls hospitalized between January 2017 and December 2019 were enrolled in this retrospective case-control study. Residential exposure to ambient air pollutants, including fine particulate matter (PM2.5), inhalable particulate (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone were estimated by satellite-models or ground measurement. Multivariate regression analyses explored the association between annual air pollutants exposure and the risk of APAC.
Of the 1011 participants (31.1% were male subjects), the average age was 64.0 years. Long-term exposure to PM2.5, PM10, and SO2 were significantly associated with an increased risk of APAC. The adjusted odds ratios (aORs) for each interquartile range (IQR) increment of PM2.5, PM10, and SO2 were 1.28 (95% confidence interval [CI] = 1.06-1.57), 1.26 (95% CI = 1.06-1.50), and 1.30 (95% CI = 1.04-1.62) separately, after controlling for confounders. Robust associations were observed for a longer lag 2-year exposure.
Long-term exposure to PM2.5, PM10, and SO2 was associated with an increased risk of APAC in a Chinese population. Our findings provide epidemiological implications on the adverse effects of air pollution on ocular diseases.
Long-term exposure to ambient air pollutants increased the risk of APAC.
本研究旨在调查长期暴露于环境空气污染物与急性原发性闭角型青光眼（APAC）风险之间的关联。
本回顾性病例对照研究纳入了2017年1月至2019年12月期间住院的281例APAC患者和730例年龄及性别匹配的对照。通过卫星模型或地面测量估算居住环境中空气污染物的暴露情况，包括细颗粒物（PM2.5）、可吸入颗粒物（PM10）、二氧化氮（NO2）、二氧化硫（SO2）和臭氧。多因素回归分析探讨了年度空气污染物暴露与APAC风险之间的关联。
在1011名参与者中（31.1%为男性），平均年龄为64.0岁。长期暴露于PM2.5、PM10和SO2与APAC风险增加显著相关。在控制混杂因素后，PM2.5、PM10和SO2每增加一个四分位数间距（IQR）的调整优势比（aOR）分别为1.28（95%置信区间[CI]=1.06-1.57）、1.26（95%CI=1.06-1.50）和1.30（95%CI=1.04-1.62）。在较长的滞后2年暴露中观察到了稳健的关联。
在中国人群中，长期暴露于PM2.5、PM10和SO2与APAC风险增加相关。我们的研究结果为空气污染对眼部疾病的不良影响提供了流行病学依据。
长期暴露于环境空气污染物会增加APAC的风险。
