Department of Optometry, Chung Shan Medical University, Taichung 40201, Taiwan.
Department of Ophthalmology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Int J Environ Res Public Health. 2021 Feb 10;18(4):1714. doi: 10.3390/ijerph18041714.
Primary open-angle glaucoma (POAG) is the most common type of glaucoma. However, little is known about POAG in adults and exposure to air pollution. The current study aims to investigate whether exposure to particulate matter with a mass median aerodynamic diameter of ≤2.5 μm (PM) is associated with POAG diagnosis. Patient data were obtained from the Longitudinal Health Insurance Database 2010 (LHID2010) of Taiwan for the 2008-2013 period. PM concentration data, collected from the Ambient Air Quality Monitoring Network established by the Environmental Protection Administration of Taiwan, were categorized into four groups according to World Health Organization (WHO) exposure standards for PM. We estimated the odds ratios (ORs) and 95% CIs for risk factors for POAG with logistic regression. The OR of per WHO standard level increase was 1.193 (95% CI 1.050-1.356). Compared with the normal level, the OR of WHO 2.0 level was 1.668 (95% CI 1.045-2.663, < 0.05). After excluding confounding risk factors for POAG in this study, we determined that increased PM exposure is related to POAG risk (ORs > 1, < 0.05). In this study, PM was an independent factor associated with open-angle glaucoma. Further research is required to better understand the mechanisms connecting PM and open-angle glaucoma.
原发性开角型青光眼（POAG）是最常见的青光眼类型。然而，人们对成年人和接触空气污染的 POAG 知之甚少。本研究旨在探讨空气中颗粒物质量中值空气动力学直径≤2.5μm（PM）的暴露是否与 POAG 诊断有关。患者数据来自台湾的 2008-2013 年纵向健康保险数据库 2010（LHID2010）。根据世界卫生组织（WHO）对 PM 的暴露标准，从台湾环境保护署建立的环境空气质量监测网络中收集的 PM 浓度数据分为四组。我们使用逻辑回归估计 POAG 风险因素的优势比（OR）和 95%置信区间（CI）。与 WHO 标准水平相比，每增加一个标准水平的 OR 为 1.193（95%CI 1.050-1.356）。与正常水平相比，WHO 2.0 水平的 OR 为 1.668（95%CI 1.045-2.663， < 0.05）。在排除本研究中 POAG 的混杂风险因素后，我们确定增加的 PM 暴露与 POAG 风险相关（OR>1， < 0.05）。在这项研究中，PM 是与开角型青光眼相关的一个独立因素。需要进一步研究以更好地了解 PM 和开角型青光眼之间的联系机制。
