Suppr超能文献

343例鼻基底细胞癌标准手术切除疗效评估及复发相关因素分析:一项单中心回顾性研究

Assessment of Standard Surgical Excision Efficacy and Analysis of Recurrence-Associated Factors in 343 Cases of Nasal Basal Cell Carcinoma: A Single-Center Retrospective Study.

作者信息

Baltrušaitytė Karolina, Zacharevskij Ernest, Pilipaitytė Loreta, Braziulis Kęstutis, Petkevičius Arūnas

机构信息

Faculty of Medicine, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.

Department of Plastic and Reconstructive Surgery, Hospital of Lithuanian University of Health Sciences Kaunas Clinics, 50161 Kaunas, Lithuania.

出版信息

Healthcare (Basel). 2024 Feb 21;12(5):513. doi: 10.3390/healthcare12050513.

Abstract

In Caucasians, basal cell carcinoma, the predominant non-melanoma skin cancer type, poses challenges for surgeons due to anatomical and aesthetic concerns, particularly when located on the nose. The study aimed to evaluate tumor distribution, size, morphological subtypes, surgical outcomes, radicality levels, and their correlation with recurrence rates. A retrospective analysis encompassed 343 cases of nasal skin cancer over a four-year period from 1 January 2019 to 31 December 2022. The research cohort comprised 252 female and 91 male participants, averaging 75.2 years old. Tumors were most found on the left sidewall of the nose (25.4%) and the dorsum (24.8%). The infiltrative morphological subtype was predominant (70.8%). Standard surgical excision with fasciocutaneous plastic was the preferred surgical procedure. Radical excision, defined by the absence of tumor cells in a resection margin, was accomplished in 79.0% of lesions, whereas 16.9% demonstrated incomplete excision, signifying the presence of tumor cells in the resection margin. Non-radically excised tumors exhibited a significantly higher recurrence rate (24.1%) compared to those with radical excision (6.3%). In nasal reconstruction, diverse surgical techniques are essential for precise adaptation based on factors like tumor characteristics and patient needs. Despite surgeons' careful adherence to excision margin guidelines, the possibility of non-radical outcome cannot be eliminated.

摘要

在白种人中,基底细胞癌是主要的非黑色素瘤皮肤癌类型,由于解剖学和美学方面的考虑,给外科医生带来了挑战,尤其是位于鼻子上的基底细胞癌。该研究旨在评估肿瘤的分布、大小、形态学亚型、手术结果、根治程度及其与复发率的相关性。一项回顾性分析涵盖了2019年1月1日至2022年12月31日这四年间的343例鼻皮肤癌病例。研究队列包括252名女性和91名男性参与者,平均年龄为75.2岁。肿瘤最常出现在鼻左侧壁(25.4%)和鼻背(24.8%)。浸润性形态学亚型占主导(70.8%)。标准外科切除联合筋膜皮瓣整形术是首选的手术方法。根治性切除定义为切除边缘无肿瘤细胞,79.0%的病变实现了根治性切除,而16.9%的病变切除不完全,表明切除边缘存在肿瘤细胞。与根治性切除的肿瘤(6.3%)相比,非根治性切除的肿瘤复发率显著更高(24.1%)。在鼻重建中,根据肿瘤特征和患者需求等因素,采用多种手术技术对于精确适配至关重要。尽管外科医生严格遵循切除边缘指南,但仍无法消除非根治性结果的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdba/10931200/02ac2eac9fce/healthcare-12-00513-g001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验