Benz Petra, Zablotski Yury, Schulz Bianka
Clinic of Small Animal Medicine, Ludwig Maximilian University of Munich, Munich, Germany.
PLoS One. 2024 Mar 12;19(3):e0299252. doi: 10.1371/journal.pone.0299252. eCollection 2024.
Pulmonary function testing by barometric whole-body plethysmography (BWBP) is a long-established and well-accepted, non-invasive investigative procedure in cats.
HYPOTHESIS/OBJECTIVES: To evaluate, if different acclimatization times influence the measurement parameters of BWBP in healthy adult cats.
48 healthy adult cats.
In the prospective observational study, healthy cats were placed in a measuring chamber and BWBP was performed over 30 minutes. Parameters obtained during the three measurement units of 10 minutes each (T1, T2 and T3) were compared.
All measurement parameters except for tidal volume per body weight changed significantly (p<0.05) over the three time periods. From T1-T2, the parameters minute volume per body weight (p<0.001), peak inspiratory flow per body weight (p<0.001), peak expiratory flow per body weight (p = 0.002), pause (p = 0.03), enhanced pause (p = 0.03) and quotient of peak expiratory flow divided by expiratory flow at end expiratory volume plus 50% tidal volume (p = 0.03) changed significantly. From the time interval T2-T3, only respiratory rate (p = 0.02), inspiratory time (p = 0.02), expiratory time (p = 0.04), and relaxation time (p = 0.01) changed significantly. All measurement parameters except for tidal volume per body weight changed significantly (p<0.05) between T1 and T3. Age had a significant influence on all parameters except for peak expiratory flow per body weight and peak inspiratory flow per body weight. The parameters were not influenced by sex.
All measurement parameters except tidal volume per body weight were significantly affected by acclimatization time. Controlling for age and sex, there was still a significant influence of acclimatization time on all parameters except for tidal volume per body weight. Standardization of the acclimatization time for future studies would be appropriate in order to maintain comparability.
通过气压式全身体积描记法（BWBP）进行肺功能测试是一种在猫身上长期确立且被广泛接受的非侵入性检查方法。
假设/目的：评估不同的适应时间是否会影响健康成年猫BWBP的测量参数。
48只健康成年猫。
在这项前瞻性观察研究中，将健康猫置于测量室中，进行30分钟的BWBP测量。比较在三个10分钟测量单元（T1、T2和T3）期间获得的参数。
除每体重潮气量外，所有测量参数在三个时间段内均有显著变化（p<0.05）。从T1到T2，每体重分钟通气量（p<0.001）、每体重吸气峰值流速（p<0.001）、每体重呼气峰值流速（p = 0.002）、暂停时间（p = 0.03）、增强暂停时间（p = 0.03）以及呼气峰值流速除以呼气末容积加50%潮气量时的呼气流速的商（p = 0.03）均有显著变化。从时间间隔T2到T3，只有呼吸频率（p = 0.02）、吸气时间（p = 0.02）、呼气时间（p = 0.04）和松弛时间（p = 0.01）有显著变化。除每体重潮气量外，所有测量参数在T1和T3之间均有显著变化（p<0.05）。年龄对除每体重呼气峰值流速和每体重吸气峰值流速外的所有参数均有显著影响。这些参数不受性别影响。
除每体重潮气量外，所有测量参数均受适应时间的显著影响。在控制年龄和性别后，适应时间对除每体重潮气量外的所有参数仍有显著影响。为保持可比性，未来研究对适应时间进行标准化是合适的。
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