普萘洛尔和索他洛尔对正常人体受试者的中枢和外周作用。
Central and peripheral effects of propranolol and sotalol in normal human subjects.
作者信息
Lader M H, Tyrer P J
出版信息
Br J Pharmacol. 1972 Jul;45(3):557-60. doi: 10.1111/j.1476-5381.1972.tb08113.x.
Abstract
No unequivocal central effects were found with either +/--propranolol (120 mg) or +/--sotalol (240 mg) in acute dosage in normal subjects. Subjective feelings of drowsiness and muzziness were found with sotalol and both sotalol and propranolol caused subjects to feel more troubled. These changes were not accompanied by physiological or behavioural evidence of sedation. Adequate beta-adrenoceptor blockade was achieved as measured by a significant fall in pulse-rate on both active drugs but no other significant peripheral physiological changes occurred.
摘要
在正常受试者中，急性剂量的±普萘洛尔（120毫克）或±索他洛尔（240毫克）均未发现明确的中枢效应。使用索他洛尔时发现有嗜睡和头晕的主观感觉，索他洛尔和普萘洛尔都会使受试者感觉更不适。这些变化并未伴有镇静的生理或行为证据。两种活性药物均使脉搏率显著下降，表明实现了充分的β-肾上腺素能受体阻滞，但未发生其他显著的外周生理变化。
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本文引用的文献
1
A comparison of hypnotic and residual psychological effects of single doses of chlorpromazine and secobarbital in man.单剂量氯丙嗪和速可巴比妥对人体的催眠及残留心理效应比较
J Pharmacol Exp Ther. 1959 Sep;127:51-4.
2
USE OF PROPRANOLOL IN ANGINA PECTORIS.普萘洛尔在心绞痛中的应用。
Br Med J. 1965 Aug 7;2(5457):337-9. doi: 10.1136/bmj.2.5457.337.
3
Hallucinations and propranolol.幻觉与普萘洛尔
Br Med J. 1969 May 17;2(5654):445. doi: 10.1136/bmj.2.5654.445.
4
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Acta Endocrinol (Copenh). 1968 Mar;57(3):353-62. doi: 10.1530/acta.0.0570353.
5
Residual effects of hypnotics.催眠药的残留效应。
Psychopharmacologia. 1972;25(2):117-32. doi: 10.1007/BF00423189.
6
Hangover effect of hypnotics in man.
Nature. 1971 Feb 26;229(5287):637-8. doi: 10.1038/229637b0.
7
Tranquillizing effects of propranolol demonstrated in rats.普萘洛尔对大鼠的镇静作用得到证实。
Neuropharmacology. 1971 Jul;10(4):453-8. doi: 10.1016/0028-3908(71)90073-6.
8
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