药物对大鼠由氧化震颤素引起的震颤及脑内乙酰胆碱增加的影响。
Effects of drugs on tremor and increase in brain acetylcholine produced by oxotremorine in the rat.
作者信息
Cox B, Potkonjak D
出版信息
Br J Pharmacol. 1970 Jan;38(1):171-80. doi: 10.1111/j.1476-5381.1970.tb10345.x.
Abstract
- In rats the effect of drugs on oxotremorine tremor and oxotremorine-induced increase in brain acetylcholine has been investigated.2. Reserpine, (+/-)-alpha-methylmetatyrosine and diethyldithio-carbamic acid, drugs which have in common the ability to decrease tissue noradrenaline concentration, inhibited oxotremorine tremor without preventing the oxotremorine-induced increase in brain acetylcholine.3. (+/-)-p-chlorophenylalanine, a depletor of tissue 5-hydroxytryptamine, did not inhibit oxotremorine tremor.4. Phenoxybenzamine and propranolol inhibited oxotremorine tremor, and propranolol was without effect on oxotremorine-induced increase in brain acetylcholine.5. The toxicity of oxotremorine was increased by reserpine and phenoxybenzamine.6. The significance of these findings is discussed with regard to the mode of action of oxotremorine.
摘要
在大鼠中，研究了药物对氧化震颤素震颤以及氧化震颤素引起的脑乙酰胆碱增加的影响。
利血平、（±）-α-甲基间酪氨酸和二乙基二硫代氨基甲酸，这些药物都具有降低组织去甲肾上腺素浓度的能力，它们抑制了氧化震颤素震颤，但并未阻止氧化震颤素引起的脑乙酰胆碱增加。
（±）-对氯苯丙氨酸，一种组织5-羟色胺的消耗剂，并未抑制氧化震颤素震颤。
酚苄明和普萘洛尔抑制了氧化震颤素震颤，且普萘洛尔对氧化震颤素引起的脑乙酰胆碱增加没有影响。
利血平和酚苄明增加了氧化震颤素的毒性。
就氧化震颤素的作用方式对这些发现的意义进行了讨论。
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Br J Pharmacol. 1970 Jan;38(1):171-80. doi: 10.1111/j.1476-5381.1970.tb10345.x.
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本文引用的文献
1
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Adv Pharmacol (1962). 1964;3:83-127. doi: 10.1016/s1054-3589(08)61111-4.
2
TREMORINE-INDUCED TREMOR VERSUS EXTRAPYRAMIDAL DISEASE.震颤素诱发的震颤与锥体外系疾病
Nature. 1964 Feb 29;201:929-30. doi: 10.1038/201929a0.
3
THE INFLUENCE OF PHENOXYBENZAMINE ON THE STORAGE OF NORADRENALINE IN RAT AND CAT TISSUES.酚苄明对大鼠和猫组织中去甲肾上腺素储存的影响
Br J Pharmacol Chemother. 1964 Feb;22(1):104-12. doi: 10.1111/j.1476-5381.1964.tb01547.x.
4
The effects of alpha-methyl-DOPA and alpha-methyl-metatyrosine on the metabolism of norepinephrine and serotonin in vivo.α-甲基多巴和α-甲基间酪氨酸对体内去甲肾上腺素和5-羟色胺代谢的影响。
J Pharmacol Exp Ther. 1961 Nov;134:129-38.
5
Oxotremorine and central monoamine neurons.氧化震颤素与中枢单胺能神经元。
Life Sci. 1967 Dec 1;6(23):2557-66. doi: 10.1016/0024-3205(67)90321-9.
6
The antagonism of oxotremorine effects in the mouse by thymoleptics.抗抑郁药对小鼠中氧代震颤素作用的拮抗作用。
Life Sci. 1966 Jun;5(11):1015-23. doi: 10.1016/0024-3205(66)90007-5.
7
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Life Sci. 1965 May;4(10):1031-6. doi: 10.1016/0024-3205(65)90222-5.
8
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