Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
Department of Psychiatry, McGill University, Montreal, QC, Canada.
Rheumatology (Oxford). 2024 Oct 1;63(10):2660-2669. doi: 10.1093/rheumatology/keae162.
To compare physical function in systemic sclerosis (SSc, scleroderma) to general population normative data and identify associated factors.
Scleroderma Patient-centered Intervention Network Cohort participants completed the Physical Function domain of the Patient-Reported Outcomes Measurement Information System Version 2 upon enrolment. Multivariable linear regression was used to assess associations of sociodemographic, lifestyle, and disease-related variables.
Among 2385 participants, the mean physical function T-score (43.7, SD = 8.9) was ∼2/3 of a standard deviation (SD) below the US general population (mean = 50, SD = 10). Factors associated in the multivariable analysis included older age (-0.74 points per SD years, 95% CI -0.78 to -1.08), female sex (-1.35, -2.37 to -0.34), fewer years of education (-0.41 points per SD in years, -0.75 to -0.07), being single, divorced, or widowed (-0.76, -1.48 to -0.03), smoking (-3.14, -4.42 to -1.85), alcohol consumption (0.79 points per SD drinks per week, 0.45-1.14), BMI (-1.41 points per SD, -1.75 to -1.07), diffuse subtype (-1.43, -2.23 to -0.62), gastrointestinal involvement (-2.58, -3.53 to -1.62), digital ulcers (-1.96, -2.94 to -0.98), moderate (-1.94, -2.94 to -0.93) and severe (-1.76, -3.24 to -0.28) small joint contractures, moderate (-2.10, -3.44 to -0.76) and severe (-2.54, -4.64 to -0.44) large joint contractures, interstitial lung disease (-1.52, -2.27 to -0.77), pulmonary arterial hypertension (-3.72, -4.91 to -2.52), rheumatoid arthritis (-2.10, -3.64 to -0.56) and idiopathic inflammatory myositis (-2.10, -3.63 to -0.56).
Physical function is impaired for many individuals with SSc and is associated with multiple disease factors.
将系统性硬化症（SSc，硬皮病）患者的身体功能与一般人群的标准数据进行比较，并确定相关因素。
硬皮病患者为中心的干预网络队列参与者在入组时完成了患者报告的结果测量信息系统版本 2 的身体功能领域。多变量线性回归用于评估社会人口统计学、生活方式和疾病相关变量的关联。
在 2385 名参与者中，身体功能 T 评分（43.7，SD=8.9）约为美国一般人群（平均=50，SD=10）标准偏差（SD）的 2/3。多变量分析中的相关因素包括年龄较大（每 SD 年减少 0.74 分，95%CI-0.78 至-1.08）、女性（-1.35，-2.37 至-0.34）、教育年限较少（每 SD 年减少 0.41 分，-0.75 至-0.07）、单身、离婚或丧偶（-0.76，-1.48 至-0.03）、吸烟（-3.14，-4.42 至-1.85）、饮酒（每周 0.79 份 SD 饮料，0.45-1.14）、BMI（每 SD 减少 1.41 分，-1.75 至-1.07）、弥漫性亚型（-1.43，-2.23 至-0.62）、胃肠道受累（-2.58，-3.53 至-1.62）、指溃疡（-1.96，-2.94 至-0.98）、中度（-1.94，-2.94 至-0.93）和严重（-1.76，-3.24 至-0.28）小关节挛缩、中度（-2.10，-3.44 至-0.76）和严重（-2.54，-4.64 至-0.44）大关节挛缩、间质性肺病（-1.52，-2.27 至-0.77）、肺动脉高压（-3.72，-4.91 至-2.52）、类风湿关节炎（-2.10，-3.64 至-0.56）和特发性炎性肌病（-2.10，-3.63 至-0.56）。
许多 SSc 患者的身体功能受损，与多种疾病因素有关。
