Liem Sophie I E, Vliet Vlieland Theodora P M, Schoones Jan W, de Vries-Bouwstra Jeska K
Department of Rheumatology, Leiden, The Netherlands.
Department of Orthopaedics, Rehabilitation Medicine and Physical Therapy, Leiden, The Netherlands.
Rheumatol Adv Pract. 2019 Dec 9;3(2):rkz044. doi: 10.1093/rap/rkz044. eCollection 2019.
Given the shortcomings of previous literature reviews evaluating the effect and safety of exercise therapy in SSc, we aimed to carry out a systematic review of the literature specifically on this topic. A structured search strategy was performed in Medline (via PubMed) and other electronic databases from 1990 to 3 September 2019. Randomized controlled trials, observational designs, conference abstracts and trial registrations were included if they concerned SSc patients ≥18 years of age, exercise therapy and reported outcomes related to physical functioning. Nine articles were included. Four randomized controlled trials compared (a) hand exercises, (b) orofacial exercises, (c) aerobic exercises or (d) aerobic exercises plus resistance training with no exercise, demonstrating effects on hand function (a), maximum mouth opening (b), peak oxygen uptake (c + d) and quality of life. All five observational studies concerning hand, orofacial, aerobic and/or strengthening exercises reported improvements of hand function, mouth opening, aerobic capacity and/or muscle strength. In conclusion, the evidence on the effect and safety of exercise therapy in SSc is scanty.
鉴于以往评估运动疗法在系统性硬化症中的疗效和安全性的文献综述存在缺陷，我们旨在专门针对这一主题进行系统的文献综述。我们于1990年至2019年9月3日在Medline（通过PubMed）和其他电子数据库中执行了结构化检索策略。如果随机对照试验、观察性设计、会议摘要和试验注册涉及年龄≥18岁的系统性硬化症患者、运动疗法以及报告的与身体功能相关的结果，则将其纳入。共纳入9篇文章。四项随机对照试验比较了（a）手部运动、（b）口面部运动、（c）有氧运动或（d）有氧运动加抗阻训练与不运动的效果，结果显示对手部功能（a）、最大张口度（b）、峰值摄氧量（c + d）和生活质量有影响。所有五项关于手部、口面部、有氧运动和/或强化运动的观察性研究均报告了手部功能、张口度、有氧运动能力和/或肌肉力量的改善。总之，关于运动疗法在系统性硬化症中的疗效和安全性的证据不足。
