Hossain Sigma, Choudhury Minhaj Rahim, Haque Md Mahmudul, Yeasmin Surayea, Hossain Farzana, Zaman Mohammad Mostafa
Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag Avenue, Dhaka, Bangladesh.
Department of Community Medicine, National Institute of Preventive and Social Medicine (NIPSOM), Dhaka, Bangladesh.
BMC Rheumatol. 2022 Sep 30;6(1):60. doi: 10.1186/s41927-022-00291-x.
To assess the relationship between functional disability and health-related quality of life (HRQoL) among systemic sclerosis (SSc) patients.
This cross-sectional study was carried out on 78 adults who met the classification criteria for SSc defined by the American College of Rheumatology/European League of Rheumatology (ACR/EULAR)-2013. The Bangla version of Short Form 36 (SF-36) and Health Assessment Questionnaire-Disability Index (HAQ-DI) were used to measure HRQoL and functional disability in SSc patients.
The patients' median [IQR] HAQ-DI was 1.4 [0.6-2.1], with 37.2% having a mild functional disability, 33.3 percent having a moderate functional disability, and 29.5 percent having a severe functional disability. The hygiene and activity domains of the HAQ-DI obtained the highest scores, 2.0 [0.0-3.0] and 2.0 [1.0-3.0], respectively. The Physical Component Summary (PCS) and Mental Component Summary (MCS) of the SF-36 had median [IQR] values of 26.2 [15.0-58.1] and 42.0 [19.6-60.6]. The highest score was 50.0 [25.0-75.0] in social functioning. The PCS of the SF-36 was moderately correlated with the HAQ-DI (r = - 0.629, P < 0.001) and the MCS of the SF-36 was weakly correlated with the HAQ-DI ((r = - 0.344, P < 0.001). Age, female sex, and incomplete fist closure substantially influenced functional status. Calcinosis, Raynaud's Phenomenon, and flexion contracture significantly diminished the quality of life.
Functional disability negatively affects health-related quality of life. Age, Musculoskeletal, and skin involvement are significantly associated with poor quality of life and functional disability. Therefore, treatment strategies should be aimed at reducing functional disability, which will enhance the HRQoL of SSc patients.
评估系统性硬化症（SSc）患者的功能残疾与健康相关生活质量（HRQoL）之间的关系。
本横断面研究对78名符合美国风湿病学会/欧洲风湿病联盟（ACR/EULAR）-2013定义的SSc分类标准的成年人进行。使用孟加拉语版简明健康调查问卷（SF-36）和健康评估问卷残疾指数（HAQ-DI）来测量SSc患者的HRQoL和功能残疾情况。
患者的HAQ-DI中位数[四分位间距]为1.4[0.6 - 2.1]，37.2%有轻度功能残疾，33.3%有中度功能残疾，29.5%有重度功能残疾。HAQ-DI的卫生和活动领域得分最高，分别为2.0[0.0 - 3.0]和2.0[1.0 - 3.0]。SF-36的身体成分总结（PCS）和精神成分总结（MCS）的中位数[四分位间距]值分别为26.2[15.0 - 58.1]和42.0[19.6 - 60.6]。社会功能领域得分最高，为50.0[25.0 - 75.0]。SF-36的PCS与HAQ-DI中度相关（r = - 0.629，P < 0.001），SF-36的MCS与HAQ-DI弱相关（r = - 0.344，P < 0.001）。年龄、女性性别和握拳不全对功能状态有显著影响。钙质沉着、雷诺现象和屈曲挛缩显著降低生活质量。
功能残疾对健康相关生活质量有负面影响。年龄、肌肉骨骼和皮肤受累与生活质量差和功能残疾显著相关。因此，治疗策略应旨在减少功能残疾，这将提高SSc患者的HRQoL。
