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[黄色肉芽肿性肾上腺炎:肾上腺肿瘤的一种罕见且难以鉴别的诊断]

[Xanthogranulomatous adrenalitis : A rare and difficult differential diagnosis of adrenal gland tumors].

作者信息

Saeger Wolfgang, Luebke Andreas M, Mekoula S T, Pahnke Jörg-Michael

机构信息

Institut für Pathologie des Universitätsklinikums Hamburg-Eppendorf, Universität Hamburg, UKE, Martinistr. 52, 20246, Hamburg, Deutschland.

Klinik für Urologie und Kinderurologie des St. Barbara-Hospital, Gladbeck, Deutschland.

出版信息

Pathologie (Heidelb). 2024 May;45(3):218-222. doi: 10.1007/s00292-024-01312-x. Epub 2024 Mar 12.

Abstract

A radiologically diagnosed tumor in a 29-year-old woman with a fever of around 39 °C was operated on under the suspicion of cholecystitis or a liver abscess. A solid tumor was found in the adrenal gland and resected. The frozen section findings did not reveal a clear diagnosis of entity and assignment. Histologically, the tumor was found to consist of densely clustered large histiocyte-like cells with expression of vimentin, CD68, and CD163 as well as negativity for keratin, langerin, and SMA. We diagnosed xanthogranulomatous adrenalitis and discussed the differential diagnoses (Langerhans cell histiocytosis, Rosai-Dorfman disease, malakoplakia, Erdheim-Chester disease).

摘要

一名29岁发热(体温约39°C)女性经放射学诊断为肿瘤,因怀疑胆囊炎或肝脓肿而接受手术。在肾上腺发现一个实性肿瘤并进行了切除。冰冻切片检查结果未能明确诊断肿瘤的实体及归属。组织学检查发现,肿瘤由密集聚集的大组织细胞样细胞组成,波形蛋白、CD68和CD163呈阳性表达,而角蛋白、朗格汉斯细胞组织细胞增生症抗原和平滑肌肌动蛋白呈阴性。我们诊断为黄色肉芽肿性肾上腺炎,并讨论了鉴别诊断(朗格汉斯细胞组织细胞增生症、罗萨伊 - 多夫曼病、软斑病、 Erdheim-Chester病)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60e0/11045564/e9f067199d38/292_2024_1312_Fig1_HTML.jpg

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