Buchmann E, Schwesinger G
Zentralbl Neurochir. 1979;40(1):35-42.
In necropsies of 165 patients with malignant haemoblastoses, infiltrates in the pituitary were found in 38 cases (23%). The most frequent occurrence was found in lymphoblastic leucosis (33.3%) and in non-Hodgkin lymphomas (29%). Hypophyseal manifestations were found in 21% for myoblastic leucosis and in 5.5% in case of Hodgkin lymphomas. As regards the location, the capsula showed an affection of 55.2%, the anterior and posterior lobes together one of 21.1%, the neurohypophysis one of 15.8% and the anterior lobe one of 7.9%. There are different opinions with regard to the development: exclusively metastatic processes or local formation of the infiltrates. The latter opinion is favoured by the frequent detection of cells of exemplary haemopoiesis between the Dorsum sellae and the outer layer of the hypophyseal capsule (Stratum periostale) in patients without haemoblastosis as well as by the fact that in half of the patients the clinical picture of meningosis leucotica only developed in the stage of haematological full remission, that is, when there were no longer any blastomatous cells in the blood.
在对165例恶性成血细胞增多症患者进行的尸检中，发现38例（23%）患者的垂体有浸润。最常见于淋巴细胞白血病（33.3%）和非霍奇金淋巴瘤（29%）。成髓细胞白血病患者垂体表现的发生率为21%，霍奇金淋巴瘤患者为5.5%。就位置而言，包膜受累占55.2%，前叶和后叶共占21.1%，神经垂体占15.8%，前叶占7.9%。关于其发展存在不同观点：是单纯的转移过程还是浸润的局部形成。后一种观点得到以下情况的支持：在无成血细胞增多症的患者中，经常在蝶鞍背与垂体包膜外层（骨膜层）之间检测到典型造血细胞；以及事实上，一半的患者仅在血液学完全缓解阶段出现白血病性脑膜炎的临床表现，即血液中不再有任何母细胞时。
