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饮食及其成分对肝细胞癌(HCC)发生发展和预防的影响。

The Influence of Diet and Its Components on the Development and Prevention of Hepatocellular Carcinoma (HCC).

作者信息

Janota Barbara, Szymanek Barbara

机构信息

Department of Basic Medical Sciences, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, 41-902 Bytom, Poland.

ID Clinic, 41-400 Mysłowice, Poland.

出版信息

Cancers (Basel). 2024 Mar 2;16(5):1030. doi: 10.3390/cancers16051030.

Abstract

Hepatocellular carcinoma (HCC) is diagnosed annually in nearly a million people worldwide, with approximately half of them being diagnosed at an advanced stage of the disease. Non-infectious risk factors for the development of HCC include an unbalanced lifestyle, including poor dietary choices characterized by a low intake of antioxidants, such as vitamins E and C, selenium, and polyphenols, as well as an excessive consumption of energy and harmful substances. Repeated bad dietary choices that contribute to an unbalanced lifestyle lead to the accumulation of fatty substances in the liver and to it entering an inflammatory state, which, without intervention, results in cirrhosis, the main cause of HCC. This review of the English language literature aims to present the food components that, when included in the daily diet, reduce the risk of developing HCC, as well as identifying foods that may have a carcinogenic effect on liver cells.

摘要

全球每年有近百万人被诊断出患有肝细胞癌(HCC),其中约一半在疾病晚期被诊断出来。HCC发生的非感染性风险因素包括生活方式不均衡,例如饮食选择不佳,其特点是抗氧化剂(如维生素E和C、硒和多酚)摄入量低,以及能量和有害物质的过度消耗。导致生活方式不均衡的反复不良饮食选择会导致肝脏中脂肪物质的积累,并使其进入炎症状态,若不加以干预,会导致肝硬化,而肝硬化是HCC的主要原因。这篇对英文文献的综述旨在介绍那些纳入日常饮食中可降低患HCC风险的食物成分,以及识别可能对肝细胞有致癌作用的食物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ea/10930424/075756f97f23/cancers-16-01030-g001.jpg

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