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树突状细胞和巨噬细胞中的P2X7受体：对抗抗原呈递和T淋巴细胞激活的影响

P2X7 Receptor in Dendritic Cells and Macrophages: Implications in Antigen Presentation and T Lymphocyte Activation.

作者信息

Acuña-Castillo Claudio, Escobar Alejandro, García-Gómez Moira, Bachelet Vivienne C, Huidobro-Toro Juan Pablo, Sauma Daniela, Barrera-Avalos Carlos

机构信息

Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.

Centro de Biotecnología Acuícola, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile.

出版信息

Int J Mol Sci. 2024 Feb 21;25(5):2495. doi: 10.3390/ijms25052495.

DOI:10.3390/ijms25052495
PMID:38473744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10931747/
Abstract

The P2X7 receptor, a member of the P2X purinergic receptor family, is a non-selective ion channel. Over the years, it has been associated with various biological functions, from modulating to regulating inflammation. However, its emerging role in antigen presentation has captured the scientific community's attention. This function is essential for the immune system to identify and respond to external threats, such as pathogens and tumor cells, through T lymphocytes. New studies show that the P2X7 receptor is crucial for controlling how antigens are presented and how T cells are activated. These studies focus on antigen-presenting cells, like dendritic cells and macrophages. This review examines how the P2X7 receptor interferes with effective antigen presentation and activates T cells and discusses the fundamental mechanisms that can affect the immune response. Understanding these P2X7-mediated processes in great detail opens up exciting opportunities to create new immunological therapies.

摘要

P2X7受体是P2X嘌呤能受体家族的成员之一，是一种非选择性离子通道。多年来，它与各种生物学功能相关，从调节炎症到调控炎症。然而，它在抗原呈递中新兴的作用引起了科学界的关注。这一功能对于免疫系统通过T淋巴细胞识别并应对外部威胁（如病原体和肿瘤细胞）至关重要。新的研究表明，P2X7受体对于控制抗原呈递方式以及T细胞激活方式至关重要。这些研究聚焦于抗原呈递细胞，如树突状细胞和巨噬细胞。本综述探讨了P2X7受体如何干扰有效的抗原呈递并激活T细胞，并讨论了可能影响免疫反应的基本机制。深入了解这些由P2X7介导的过程为开发新的免疫疗法带来了令人兴奋的机遇。

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本文引用的文献

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