Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.
Graduate Institute of Clinical Medicine Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Int J Mol Sci. 2024 Feb 28;25(5):2783. doi: 10.3390/ijms25052783.
Acute kidney injury is a common and complex complication that has high morality and the risk for chronic kidney disease among survivors. The accuracy of current AKI biomarkers can be affected by water retention and diuretics. Therefore, we aimed to identify a urinary non-recovery marker of acute kidney injury in patients with acute decompensated heart failure. We used the isobaric tag for relative and absolute quantification technology to find a relevant marker protein that could divide patients into control, acute kidney injury with recovery, and acute kidney injury without recovery groups. An enzyme-linked immunosorbent assay of the endothelial cell protein C receptor (EPCR) was used to verify the results. We found that the EPCR was a usable marker for non-recovery renal failure in our setting with the area under the receiver operating characteristics 0.776 ± 0.065; 95%CI: 0.648-0.905, ( < 0.001). Further validation is needed to explore this possibility in different situations.
急性肾损伤是一种常见且复杂的并发症，在幸存者中具有高死亡率和慢性肾脏病风险。目前 AKI 生物标志物的准确性可能会受到水潴留和利尿剂的影响。因此，我们旨在确定急性失代偿性心力衰竭患者急性肾损伤的尿液无恢复标志物。我们使用相对和绝对定量技术的等压标签来寻找相关的标记蛋白，这些蛋白可以将患者分为对照组、急性肾损伤恢复组和急性肾损伤未恢复组。通过酶联免疫吸附试验检测内皮细胞蛋白 C 受体 (EPCR) 来验证结果。我们发现，在我们的研究环境中，EPCR 是一种可用于非恢复性肾衰竭的标志物，其受试者工作特征曲线下面积为 0.776 ± 0.065；95%CI：0.648-0.905，（<0.001）。需要进一步的验证来探索这种可能性在不同情况下。
