Department of Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou 510275, China.
College of Arts and Sciences, Saint Louis University, St. Louis, MO 63108, USA.
Nutrients. 2024 Feb 22;16(5):593. doi: 10.3390/nu16050593.
Some studies suggest an association between iron overload and cardiovascular diseases (CVDs). However, the relationship between dietary iron intake and atrial fibrillation (AF) remains uncertain, as does the role of genetic loci on this association. The study involved 179,565 participants from UK Biobank, tracking incident atrial fibrillation (AF) cases. Iron intake was categorized into low, moderate, and high groups based on dietary surveys conducted from 2009 to 2012. The Cox regression model was used to estimate the risk of AF in relation to iron intake, assessing the hazard ratio (HR) and 95% confidence interval (95% CI). It also examined the impact of 165 AF-related and 20 iron-related genetic variants on this association. Pathway enrichment analyses were performed using Metascape and FUMA. During a median follow-up period of 11.6 years, 6693 (3.97%) incident AF cases were recorded. A total of 35,874 (20.0%) participants had high iron intake. High iron intake was associated with increased risk of AF [HR: 1.13 (95% CI: 1.05, 1.22)] in a fully adjusted model. Importantly, there were 83 SNPs (11 iron-related SNPs) that could enhance the observed associations. These genes are mainly involved in cardiac development and cell signal transduction pathways. High dietary iron intake increases the risk of atrial fibrillation, especially when iron intake exceeds 16.95 mg. The association was particularly significant among the 83 SNPs associated with AF and iron, the individuals with these risk genes. Gene enrichment analysis revealed that these genes are significantly involved in cardiac development and cell signal transduction processes.
一些研究表明铁过载与心血管疾病（CVDs）之间存在关联。然而，膳食铁摄入量与心房颤动（AF）之间的关系尚不确定，遗传基因座在这种关联中的作用也不确定。这项研究涉及来自英国生物库的 179565 名参与者，追踪心房颤动（AF）的发病情况。根据 2009 年至 2012 年进行的饮食调查，将铁摄入量分为低、中、高三组。使用 Cox 回归模型来评估铁摄入量与 AF 风险之间的关系，评估危险比（HR）和 95%置信区间（95%CI）。还检查了 165 个与 AF 相关和 20 个与铁相关的遗传变异对这种关联的影响。使用 Metascape 和 FUMA 进行途径富集分析。在中位随访 11.6 年期间，记录到 6693 例（3.97%）新发 AF 病例。共有 35874 名（20.0%）参与者铁摄入量较高。在完全调整的模型中，高铁摄入量与 AF 风险增加相关[HR：1.13（95%CI：1.05，1.22）]。重要的是，有 83 个 SNP（11 个与铁相关的 SNP）可以增强观察到的关联。这些基因主要参与心脏发育和细胞信号转导途径。高膳食铁摄入量增加心房颤动的风险，尤其是当铁摄入量超过 16.95mg 时。在与 AF 和铁相关的 83 个 SNP 中，尤其是与这些风险基因相关的个体中，这种关联尤为显著。基因富集分析表明，这些基因在心脏发育和细胞信号转导过程中发挥着重要作用。
