Pellowski Denny, Kusch Paula, Henning Thorsten, Kochlik Bastian, Maares Maria, Schmiedeskamp Amy, Pohl Gabriele, Schreiner Monika, Baldermann Susanne, Haase Hajo, Schwerdtle Tanja, Grune Tilman, Weber Daniela
Department Food Chemistry, Institute of Nutritional Science, University of Potsdam, 14469 Potsdam, Germany.
NutriAct Competence Cluster Nutrition Research Berlin-Potsdam, 14558 Nuthetal, Germany.
Nutrients. 2024 Feb 23;16(5):625. doi: 10.3390/nu16050625.
This study explores age- and time-dependent variations in postprandial micronutrient absorption after a micronutrient-rich intervention meal within the Biomiel (bioavailability of micronutrients in elderly) study. Comprising 43 healthy participants, the study compares young (n = 21; mean age 26.90 years) and old (n = 22; mean age 66.77 years) men and women, analyzing baseline concentrations and six-hour postprandial dynamics of iron (Fe), copper (Cu), zinc (Zn), selenium (Se), iodine (I), free zinc (fZn), vitamin C, retinol, lycopene, β-carotene, α-tocopherol, and γ-tocopherol, along with 25(OH) vitamin D (quantified only at baseline). Methodologically, quantifications in serum or plasma were performed at baseline and also at 90, 180, 270, and 360 min postprandially. Results reveal higher baseline serum Zn and plasma lycopene concentrations in the young group, whereas Cu, Se, Cu/Zn ratio, 25(OH) vitamin D, α-tocopherol, and γ-tocopherol were higher in old participants. Postprandial variability of Zn, vitamin C, and lycopene showed a strong time-dependency. Age-related differences in postprandial metabolism were observed for Se, Cu, and I. Nevertheless, most of the variance was explained by individuality. Despite some limitations, this study provides insights into postprandial micronutrient metabolism (in serum/plasma), emphasizing the need for further research for a comprehensive understanding of this complex field. Our discoveries offer valuable insights for designing targeted interventions to address and mitigate micronutrient deficiencies in older adults, fostering optimal health and well-being across the lifespan.
本研究在“生物米埃尔（老年人微量营养素的生物利用度）”研究中，探讨了富含微量营养素的干预餐后餐后微量营养素吸收的年龄和时间依赖性变化。该研究包括43名健康参与者，比较了年轻组（n = 21；平均年龄26.90岁）和老年组（n = 22；平均年龄66.77岁）的男性和女性，分析了铁（Fe）、铜（Cu）、锌（Zn）、硒（Se）、碘（I）、游离锌（fZn）、维生素C、视黄醇、番茄红素、β-胡萝卜素、α-生育酚和γ-生育酚的基线浓度以及餐后6小时的动态变化，同时还检测了25(OH)维生素D（仅在基线时进行定量）。在方法上，分别在基线以及餐后90、180、270和360分钟对血清或血浆进行定量分析。结果显示，年轻组的基线血清锌和血浆番茄红素浓度较高，而老年参与者的铜、硒、铜/锌比值、25(OH)维生素D、α-生育酚和γ-生育酚浓度较高。锌、维生素C和番茄红素的餐后变异性呈现出强烈的时间依赖性。观察到硒、铜和碘在餐后代谢方面存在年龄相关差异。然而，大部分变异是由个体差异引起的。尽管存在一些局限性，但本研究为餐后微量营养素代谢（在血清/血浆中）提供了见解，强调了进一步研究以全面理解这一复杂领域的必要性。我们的发现为设计针对性干预措施提供了有价值的见解，以解决和减轻老年人的微量营养素缺乏问题，促进整个生命周期的最佳健康和福祉。
