Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, 2417 Nicosia, Cyprus.
Research Centre for Exercise and Nutrition (RECEN), 2417 Nicosia, Cyprus.
Nutrients. 2024 Feb 26;16(5):660. doi: 10.3390/nu16050660.
This systematic review aimed to identify different gut microbiome profiles across the human lifespan and to correlate such profiles with the body composition. PubMed, Scopus, and Cochrane were searched from inception to March 2022. Sixty studies were included in this systematic review. Overall, the gut microbiome composition in overweight participants exhibited decreased α-diversity, decreased levels of the phylum and its taxa, and increased levels of the phylum , its taxa, and the / ratio, in comparison to normal-weight participants. Other body composition parameters showed similar correlations. Fat mass and waist circumference were found to correlate positively with the taxa and negatively with the taxa. In contrast, lean body mass and muscle mass demonstrated a positive correlation with the taxa. Notably, these correlations were more pronounced in athletes than in obese and normal-weight individuals. The composition of the gut microbiome is evidently different in overweight individuals or athletes of all age groups, with the former tending towards decreased taxa and increased taxa, while a reversed relationship is observed concerning athletes. Further studies are needed to explore the dynamic relationship between energy intake, body composition, and the gut microbiome across the human lifespan.
本系统评价旨在确定人体整个生命周期中不同的肠道微生物组谱，并将这些谱与身体成分相关联。从建立到 2022 年 3 月，我们在 PubMed、Scopus 和 Cochrane 上进行了搜索。本系统评价共纳入 60 项研究。总的来说，与正常体重参与者相比，超重参与者的肠道微生物组组成表现为 α 多样性降低、门及其分类群水平降低，而门及其分类群和 / 比水平升高。其他身体成分参数也表现出类似的相关性。脂肪量和腰围与门及其分类群呈正相关，与门及其分类群呈负相关。相比之下，瘦体重和肌肉量与门及其分类群呈正相关。值得注意的是，这些相关性在运动员中比肥胖和正常体重个体中更为明显。超重个体或所有年龄段的运动员的肠道微生物组组成显然不同，前者倾向于减少门及其分类群，增加门及其分类群，而运动员则呈现相反的关系。需要进一步的研究来探索整个生命周期中能量摄入、身体成分和肠道微生物组之间的动态关系。
