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在儿科和青少年患者群体中进行筛查发现各年龄组口腔患病率存在差异。

Screening for in a Pediatric and Adolescent Patient Population Reveals Differential Oral Prevalence across Age Groups.

作者信息

Hendricks Katelyn, Hatch Tyler, Kingsley Karl, Howard Katherine M

机构信息

Department of Advanced Education in Pediatric Dentistry, School of Dental Medicine, University of Nevada-Las Vegas, 1700 West Charleston Blvd, Las Vegas, NV 89106, USA.

Department of Clinical Sciences, School of Dental Medicine, University of Nevada-Las Vegas, 1700 West Charleston Blvd, Las Vegas, NV 89106, USA.

出版信息

Int J Environ Res Public Health. 2024 Mar 23;21(4):391. doi: 10.3390/ijerph21040391.

Abstract

, a gram-negative anaerobe usually present in periodontitis, may be linked to overweight and obese adults. Recent advancements include a valid qPCR screening, enabling an effective prevalence study among pediatric patients aged 7 to 17 years. The aim of this study was to complete a retrospective screening of saliva samples from an existing biorepository using a validated qPCR screening protocol. The pediatric study sample ( = 87) comprised nearly equal numbers of males and females, mostly minority patients (67%), with an average age of 13.2 years. Screening for revealed 34.4% ( = 30/87) positive samples, evenly distributed between males and females ( = 0.5478). However, an age-dependent association was observed with higher percentages of positive samples observed with higher ages (13.3% among 7 to 10 years; 34.6% among 11 to 13 years; 54.8% among 14-17 years), which was statistically significant ( = 0.0001). Although these findings revealed no noteworthy distinctions between males or females and minorities and non-minorities, the notable contrast between younger (7 to 10 years) and older (11 to 17 years) participants, possibly influenced by factors such as hormones and behavioral traits, will require further investigation of this patient population.

摘要

一种通常存在于牙周炎中的革兰氏阴性厌氧菌,可能与超重和肥胖的成年人有关。最近的进展包括有效的定量聚合酶链反应(qPCR)筛查,这使得在7至17岁的儿科患者中进行有效的患病率研究成为可能。本研究的目的是使用经过验证的qPCR筛查方案,对来自现有生物样本库的唾液样本进行回顾性筛查。儿科研究样本(n = 87)中男性和女性数量几乎相等,大多数为少数族裔患者(67%),平均年龄为13.2岁。对[该菌]的筛查显示34.4%(n = 30/87)的样本呈阳性,在男性和女性之间均匀分布(p = 0.5478)。然而,观察到年龄依赖性关联,年龄较大者阳性样本百分比更高(7至10岁者中为13.3%;11至13岁者中为34.6%;14至17岁者中为54.8%),这具有统计学意义(p = 0.0001)。尽管这些发现显示男性或女性以及少数族裔和非少数族裔之间没有显著差异,但年轻(7至10岁)和年长(11至17岁)参与者之间的显著差异,可能受激素和行为特征等因素影响,将需要对该患者群体进行进一步研究。 (注:原文中部分关键菌名未给出具体英文,这里用[该菌]表示,实际翻译时应补充完整菌名英文)

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8cd/11049996/e2e0c24622c1/ijerph-21-00391-g001.jpg

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