Khan Sara, Amin Faiza, Amin Rafat, Kumar Naresh
Department of Science of Dental Materials, Dr. Ishrat Ul Ebad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi 74200, Pakistan.
Department of Science of Dental Materials, Dow Dental College, Dow University of Health Sciences, Karachi 74200, Pakistan.
Polymers (Basel). 2024 Feb 21;16(5):588. doi: 10.3390/polym16050588.
The aim of this study was to evaluate the effect of cetylpyridinium chloride (CPC) addition on the antibacterial and surface hardness characteristics of two commercial resin-based dental composites (RBDCs). A total of two hundred and seventy ( = 270) specimens from Filtek Z250 Universal and Filtek Z350 XT flowable RBDCs were fabricated with the addition of CPC at 2 %wt and 4 %wt concentrations to assess their antibacterial activity using the agar diffusion test and direct contact inhibition test, and their surface hardness using the Vickers microhardness test after 1 day, 30 days, and 90 days of aging. A surface morphology analysis of the specimens was performed using a scanning electron microscope (SEM). The RBDCs that contained 2 %wt and 4 %wt CPC demonstrated significant antibacterial activity against up to 90 days, with the highest activity observed for the 4 %wt concentration. Nevertheless, there was a reduction in antibacterial effectiveness over time. Moreover, compared to the control (0 %wt) and 2 %wt CPC groups, the universal RBDCs containing 4 %wt CPC exhibited a notable decrease in surface hardness, while all groups showed a decline in hardness over time. In conclusion, the satisfactory combination of the antibacterial effect and surface hardness property of RBDCs was revealed with the addition of a 2 %wt CPC concentration.
本研究的目的是评估添加氯化十六烷基吡啶（CPC）对两种市售树脂基牙科复合材料（RBDC）的抗菌和表面硬度特性的影响。从Filtek Z250通用型和Filtek Z350 XT流动型RBDC制备了总共270个样本，添加2%重量和4%重量浓度的CPC，使用琼脂扩散试验和直接接触抑制试验评估其抗菌活性，并在老化1天、30天和90天后使用维氏显微硬度测试评估其表面硬度。使用扫描电子显微镜（SEM）对样本进行表面形态分析。含有2%重量和4%重量CPC的RBDC在长达90天的时间内表现出显著的抗菌活性，4%重量浓度的抗菌活性最高。然而，抗菌效果随时间有所下降。此外，与对照组（0%重量）和2%重量CPC组相比，含有4%重量CPC的通用型RBDC表面硬度显著降低，而所有组的硬度均随时间下降。总之，添加2%重量浓度的CPC可使RBDC的抗菌效果和表面硬度特性达到令人满意的组合。
