McCrossan Paddy, Shields Michael D, McElnay James C
Paediatric Respiratory Medicine, Royal Belfast Hospital for Sick Children, Belfast, Northern Ireland.
Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland.
Patient Prefer Adherence. 2024 Mar 5;18:555-564. doi: 10.2147/PPA.S445534. eCollection 2024.
Asthma is the most common chronic disease in childhood. If untreated, asthma can lead to debilitating daily symptoms which affect quality of life, but more importantly can lead to fatal asthma attacks which unfortunately still occur globally. The most effective treatment strategy for controlling asthma is for the patient to follow a personalised asthma action plan (PAAP) which will invariably include regular use of an inhaled corticosteroid. To examine medication adherence in children with asthma, we collated recent evidence from systematic reviews in this area to address the following 5 key questions; What is adherence? Is there evidence that children are not adhering to preventer medication? Why is adherence poor and what are the barriers to adherence? Does good adherence improve outcomes in asthma? And lastly, how can treatment adherence be improved?
哮喘是儿童期最常见的慢性疾病。若不治疗,哮喘会导致使人虚弱的日常症状,影响生活质量,但更重要的是会引发致命的哮喘发作,而不幸的是,这种情况在全球仍有发生。控制哮喘最有效的治疗策略是让患者遵循个性化哮喘行动计划(PAAP),该计划通常会包括定期使用吸入性糖皮质激素。为了研究哮喘儿童的用药依从性,我们整理了该领域系统评价的最新证据,以回答以下5个关键问题:什么是依从性?是否有证据表明儿童未坚持使用预防药物?为什么依从性差,依从性的障碍有哪些?良好的依从性是否能改善哮喘的治疗效果?最后,如何提高治疗依从性?