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模拟转移性恶性肿瘤的肝泡型包虫病

Hepatic alveolar echinococcosis simulating metastatic malignancy.

作者信息

Mitra Suvradeep, Charaya Payal, Deshpande Shrinath Gururaj, Parkhi Mayur, Yadav Thakur Deen

机构信息

Post Graduate Institute of Medical Education and Research, Department of Histopathology, Chandigarh, India.

Post Graduate Institute of Medical Education and Research, Department of GI Surgery, HPB, and Liver Transplantation, Chandigarh, India.

出版信息

Autops Case Rep. 2024 Feb 8;14:e2024474. doi: 10.4322/acr.2024.474. eCollection 2024.

Abstract

Echinococcosis is a parasitic disease caused by infection with tiny tapeworms of the genus . Echinococcosis is classified as either cystic echinococcosis or alveolar echinococcosis. The common form is a zoonosis from goats and sheep that tends to cause liver lesions. The larval stage of causes alveolar echinococcosis/alveolar hydatid disease. It is a zoonosis with field mice and tundra voles as intermediate and wild carnivores like foxes and wolves as definitive hosts. This zoonosis is highly uncommon compared to the other form known as cystic echinococcosis but poses a great human threat if untreated. We report the case of a young man who was working in the Kashmir Valley, North India, and presented with jaundice and right upper quadrant abdominal pain. Computed tomography revealed a large solid-cystic intrahepatic lesion measuring 125x118x123 mm, suggestive of a malignant tumor with central necrosis. A liver biopsy showed necrosis with PAS-positive membranes morphologically consistent with echinococcosis. Alveolar echinococcosis can present as a solid-cystic mass in the liver and can simulate metastatic malignancy.

摘要

棘球蚴病是一种由棘球绦虫属微小绦虫感染引起的寄生虫病。棘球蚴病分为囊型棘球蚴病或泡型棘球蚴病。常见形式是一种源自山羊和绵羊的人畜共患病,往往会导致肝脏病变。棘球绦虫的幼虫阶段会引发泡型棘球蚴病/肺泡型包虫病。它是一种人畜共患病,以田鼠和苔原田鼠作为中间宿主,狐狸和狼等野生食肉动物作为终宿主。与另一种称为囊型棘球蚴病的形式相比,这种人畜共患病非常罕见,但如果不治疗,会对人类构成巨大威胁。我们报告了一名在印度北部克什米尔山谷工作的年轻男子的病例,他出现黄疸和右上腹腹痛。计算机断层扫描显示肝内有一个巨大的实性-囊性病变,大小为125×118×123毫米,提示为伴有中央坏死的恶性肿瘤。肝脏活检显示坏死,PAS阳性膜在形态上与棘球蚴病一致。泡型棘球蚴病可表现为肝脏中的实性-囊性肿块,并可模拟转移性恶性肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5862/10927241/1c049102517e/autopsy-14-e2024474-g01.jpg

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