焦虑和抑郁作为额颞叶痴呆和阿尔茨海默病的风险因素：HUNT研究
Anxiety and Depression as Risk Factors in Frontotemporal Dementia and Alzheimer's Disease: The HUNT Study.
作者信息
Rasmussen Hege, Rosness Tor Atle, Bosnes Ole, Salvesen Øyvind, Knutli Marlen, Stordal Eystein
机构信息
Namsos Hospital, Clinic for Mental Health and Substance Abuse, Nord-Trøndelag Hospital Trust (HNT), Namsos, Norway.
Department of Mental Health, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
出版信息
Dement Geriatr Cogn Dis Extra. 2018 Nov 22;8(3):414-425. doi: 10.1159/000493973. eCollection 2018 Sep-Dec.
BACKGROUND
The roles of both anxiety and depression as risk factors for frontotemporal dementia (FTD) and Alzheimer's disease (AD) have not been previously investigated together.
OBJECTIVE
To study anxiety and depression as independent risk factors for FTD and AD.
METHODS
Eighty-four patients with FTD and 556 patients with AD were compared with 117 cognitively healthy (CH), elderly individuals. Both cases and controls were participants in the second Health Study of Nord-Trøndelag (HUNT2) from 1995 to 1997, in which depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS).
RESULTS
Significant associations were found between anxiety and FTD and between depression and AD. A significantly increased risk of developing FTD was observed in patients who had reported anxiety on the HADS ( = 0.017) (odds ratio [OR]: 2.947, 95% confidence interval [CI]: 1.209-7.158) and a significantly increased risk of developing AD was observed in patients who had reported depression on the HADS ( = 0.016) (OR: 4.389, 95% CI: 1.311-14.690).
CONCLUSION
Our study findings suggest that anxiety and depression may play different roles as risk factors for FTD and AD.
背景
焦虑和抑郁作为额颞叶痴呆（FTD）和阿尔茨海默病（AD）风险因素的作用此前尚未一同进行研究。
目的
研究焦虑和抑郁作为FTD和AD的独立风险因素。
方法
将84例FTD患者和556例AD患者与117名认知健康的老年个体进行比较。病例组和对照组均为1995年至1997年参加北特伦德拉格郡第二次健康研究（HUNT2）的参与者，其中使用医院焦虑抑郁量表（HADS）对抑郁和焦虑进行评估。
结果
发现焦虑与FTD之间以及抑郁与AD之间存在显著关联。在HADS上报告有焦虑的患者中观察到发生FTD的风险显著增加（P = 0.017）（比值比[OR]：2.947，95%置信区间[CI]：1.209 - 7.158），在HADS上报告有抑郁的患者中观察到发生AD的风险显著增加（P = 0.016）（OR：4.389，95% CI：1.311 - 14.690）。
结论
我们的研究结果表明，焦虑和抑郁作为FTD和AD的风险因素可能发挥不同作用。
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