Petkus Andrew J, Reynolds Chandra A, Wetherell Julie Loebach, Kremen William S, Pedersen Nancy L, Gatz Margaret
Department of Psychology, University of Southern California, Los Angeles, CA, USA.
Department of Psychology, University of California, Riverside, CA, USA.
Alzheimers Dement. 2016 Apr;12(4):399-406. doi: 10.1016/j.jalz.2015.09.008. Epub 2015 Nov 6.
We asked whether anxiety is associated with prospective risk of dementia, and the extent to which genetic influences mediate this association.
Nondemented twins (n = 1082) from the Swedish Adoption Twin Study of Aging completed an assessment of anxiety symptoms in 1984 and were followed for 28 years.
Baseline anxiety score, independent of depressive symptoms, was significantly associated with incident dementia over follow-up (hazard ratio [HR] = 1.04; 95% confidence interval [CI] = 1.01-1.06). There was 48% increased risk of becoming demented for those who had experienced high anxiety at any time compared with those who had not. In co-twin analyses, the association between anxiety symptoms and dementia was greater for dizygotic (HR = 1.11; 95% CI = 1.02-1.20) compared with monozygotic twins (HR = 1.06; 95% CI = 0.95-1.20), indicating genetic mediation.
Anxiety symptoms were associated with increased risk of dementia. Genetic factors common to dementia and anxiety partially mediated this association.
我们探讨了焦虑是否与痴呆症的前瞻性风险相关，以及基因影响在多大程度上介导了这种关联。
来自瑞典老年收养双胞胎研究的非痴呆双胞胎（n = 1082）于1984年完成了焦虑症状评估，并随访了28年。
在随访期间，独立于抑郁症状的基线焦虑评分与痴呆症的发生显著相关（风险比[HR]=1.04；95%置信区间[CI]=1.01 - 1.06）。与未经历过高度焦虑的人相比，任何时候经历过高度焦虑的人患痴呆症的风险增加了48%。在双胞胎分析中，与同卵双胞胎（HR = 1.06；95% CI = 0.95 - 1.20）相比，异卵双胞胎（HR = 1.11；95% CI = 1.02 - 1.20）的焦虑症状与痴呆症之间的关联更大，表明存在基因介导作用。
焦虑症状与痴呆症风险增加相关。痴呆症和焦虑症共有的遗传因素部分介导了这种关联。
