吸烟与肥胖作为额颞叶痴呆和阿尔茨海默病的风险因素：HUNT研究
Smoking and Obesity as Risk Factors in Frontotemporal Dementia and Alzheimer's Disease: The HUNT Study.
作者信息
Rasmussen Eid Hege, Rosness Tor Atle, Bosnes Ole, Salvesen Øyvind, Knutli Marlen, Stordal Eystein
机构信息
Clinic for Mental Health and Substance Abuse, Namsos Hospital, North-Trøndelag Hospital Trust, Namsos, Norway.
Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
出版信息
Dement Geriatr Cogn Dis Extra. 2019 Jan 9;9(1):1-10. doi: 10.1159/000495607. eCollection 2019 Jan-Apr.
BACKGROUND
Few studies have assessed smoking and obesity together as risk factors for frontotemporal dementia (FTD) and Alzheimer's disease (AD).
OBJECTIVE
To study smoking and obesity as risk factors for FTD and AD.
METHODS
Ninety patients with FTD and 654 patients with AD were compared with 116 cognitively healthy elderly individuals in a longitudinal design with 15-31 years between measurements of risk factors before the dementia diagnosis.
RESULTS
There were no associations between smoking and FTD ( = 0.218; odds ratio [OR]: 0.990; 95% confidence interval [CI]: 0.975-1.006). There were significant associations between obesity and FTD ( = 0.049; OR: 2.629; 95% CI: 1.003-6.894). There were significant associations between both smoking ( = 0.014; OR: 0.987; 95% CI: 0.977-0.997) and obesity ( = 0.015; OR: 2.679; 95% CI: 1.211-5.928) and AD.
CONCLUSION
Our findings suggest that obesity is a shared risk factor for FTD and AD, while smoking plays various roles as a risk factor for FTD and AD.
背景
很少有研究将吸烟和肥胖作为额颞叶痴呆（FTD）和阿尔茨海默病（AD）的风险因素一起进行评估。
目的
研究吸烟和肥胖作为FTD和AD的风险因素。
方法
在一项纵向研究中，将90例FTD患者和654例AD患者与116名认知健康的老年人进行比较，在痴呆诊断前对风险因素进行测量，两次测量间隔15至31年。
结果
吸烟与FTD之间无关联（P = 0.218；优势比[OR]：0.990；95%置信区间[CI]：0.975 - 1.006）。肥胖与FTD之间存在显著关联（P = 0.049；OR：2.629；95% CI：1.003 - 6.894）。吸烟（P = 0.014；OR：0.987；95% CI：0.977 - 0.997）和肥胖（P = 0.015；OR：2.679；95% CI：1.211 - 5.928）与AD均存在显著关联。
结论
我们的研究结果表明，肥胖是FTD和AD的共同风险因素，而吸烟作为FTD和AD的风险因素发挥着不同作用。
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