Xu Pan, Xu Heng, Lu Qiaoqiao, Ling Shanshan, Hu E, Song Ying, Liu Jie, Yi Bixia
Department of Gynecology, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua, Zhejiang 321000, P.R. China.
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China.
Exp Ther Med. 2024 Feb 29;27(4):175. doi: 10.3892/etm.2024.12463. eCollection 2024 Apr.
The present study aimed to investigate the reproductive outcomes of copper-containing intrauterine devices (IUDs) after hysteroscopic lysis in patients with mild to severe intrauterine adhesions (IUAs), according to the American Fertility Society (AFS) classification. Therefore, a prospective randomized controlled study was conducted at the Affiliated Jinhua Hospital of Wenzhou Medical University (Jinhua, China). A total of 173 women with IUAs were initially recruited between January 2020 and June 2021 and were then randomized to the copper-containing IUD group or the no barrier device group. Following hysteroscopic procedure, the fertility and obstetric outcomes were analyzed. Among the 173 patients enrolled, a total of 109 participants completed the study protocol. The results showed that AFS scores were not significantly different between the two groups prior to hysteroscopy. In addition, no statistically significant differences were recorded in pregnancy and live birth rates between the copper-containing IUD and no barrier device groups. Overall, the results of the current study indicated that the copper-containing IUDs had no positive effect on pregnancy and live birth rates in patients with mild to severe IUAs after hysteroscopic adhesiolysis. The present trial was retrospectively registered in the Chinese Clinical Trial Registry on 28th December 2023 (registration no. ChiCTR2300079233).
本研究旨在根据美国生育协会（AFS）分类法，调查宫腔镜粘连松解术后，轻度至重度宫腔粘连（IUA）患者使用含铜宫内节育器（IUD）的生殖结局。因此，在温州医科大学附属金华医院（中国金华）进行了一项前瞻性随机对照研究。2020年1月至2021年6月期间，共招募了173例IUA患者，随后将其随机分为含铜IUD组或无屏障装置组。宫腔镜手术后，对生育和产科结局进行分析。在纳入的173例患者中，共有109例参与者完成了研究方案。结果显示，宫腔镜检查前两组的AFS评分无显著差异。此外，含铜IUD组和无屏障装置组在妊娠率和活产率方面未记录到统计学上的显著差异。总体而言，本研究结果表明，宫腔镜粘连松解术后，含铜IUD对轻度至重度IUA患者的妊娠率和活产率没有积极影响。本试验于2023年12月28日在中国临床试验注册中心进行回顾性注册（注册号：ChiCTR2300079233）。
