Australian Research Council Centre of Excellence for Transformative Meta-Optical Systems, Department of Electronic Materials Engineering, Research School of Physics, The Australian National University, Canberra, ACT, 2600, Australia.
Commonwealth Scientific and Industrial Research Organisation (CSIRO), Mineral Resources, Private Bag 10, Clayton South, VIC, 3169, Australia.
Adv Sci (Weinh). 2024 May;11(19):e2309481. doi: 10.1002/advs.202309481. Epub 2024 Mar 13.
Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes characterized by the accumulation of ketone bodies in the blood. Breath acetone, a ketone, directly correlates with blood ketones. Therefore, monitoring breath acetone can significantly enhance the safety and efficacy of diabetes care. In this work, the design and fabrication of an InP/Pt/chitosan nanowire array-based chemiresistive acetone sensor is reported. By incorporation of chitosan as a surface-functional layer and a Pt Schottky contact for efficient charge transfer processes and photovoltaic effect, self-powered, highly selective acetone sensing is achieved. The sensor has exhibited an ultra-wide acetone detection range from sub-ppb to >100 000 ppm level at room temperature, covering those in the exhaled breath from healthy individuals (300-800 ppb) to people at high risk of DKA (>75 ppm). The nanowire sensor has also been successfully integrated into a handheld breath testing prototype, the Ketowhistle, which can successfully detect different ranges of acetone concentrations in simulated breath samples. The Ketowhistle demonstrates the immediate potential for non-invasive ketone monitoring for people living with diabetes, in particular for DKA prevention.
糖尿病酮症酸中毒 (DKA) 是一种危及生命的糖尿病急性并发症，其特征是血液中酮体的积累。呼吸中的丙酮是一种酮，与血液中的酮直接相关。因此，监测呼吸中的丙酮可以显著提高糖尿病护理的安全性和效果。在这项工作中，报告了一种基于 InP/Pt/壳聚糖纳米线阵列的电阻式丙酮传感器的设计和制造。通过将壳聚糖作为表面功能层和 Pt 肖特基接触纳入其中，以实现高效的电荷转移过程和光伏效应，实现了自供电、高选择性的丙酮传感。该传感器在室温下表现出超宽的丙酮检测范围，从亚 ppb 到 >100000 ppm 级别，涵盖了健康个体（300-800 ppb）到 DKA 高风险个体（>75 ppm）的呼气中的丙酮。纳米线传感器还成功集成到手持式呼吸测试原型中，即 Ketowhistle，它可以成功检测模拟呼吸样本中不同范围的丙酮浓度。Ketowhistle 展示了非侵入性酮监测对糖尿病患者的即时潜力，特别是对 DKA 预防的潜力。
