长非编码 RNA 对 Th17/Treg 分化和失衡的调控作用。
Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance.
机构信息
Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran AND Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Iran J Allergy Asthma Immunol. 2023 Dec 28;22(6):512-526. doi: 10.18502/ijaai.v22i6.14641.
Scientific research over the past decades has proven the pivotal role of long non-coding RNAs (LncRNAs) in regulating gene expression. The immune responses are controlled through the interaction of pro-inflammatory (predominance of T helper 17 cells (Th17)) and anti-inflammatory cytokines excretion (predominance of Regulatory T cells (Treg)). Recent studies have marked the impact of many diverse LncRNAs on Treg/Th17 imbalances. Moreover, some of the roots and causes of human diseases can be associated with the alterations in the Th17/Treg ratio. In this review study, we overviewed the association between LncRNAs and Th17/Treg, with the potential of providing novel prognostic and diagnostic biomarkers and promising therapeutic targets in various diseases, particularly cancer.
在过去几十年的科学研究中，长链非编码 RNA（lncRNAs）在调节基因表达方面的关键作用已得到证实。免疫反应是通过促炎（辅助性 T 细胞 17 细胞（Th17）为主导）和抗炎细胞因子分泌（调节性 T 细胞（Treg）为主导）的相互作用来控制的。最近的研究表明，许多不同的 lncRNAs 对 Treg/Th17 失衡有影响。此外，人类疾病的一些根源和原因可能与 Th17/Treg 比值的改变有关。在这项综述研究中，我们综述了 lncRNAs 与 Th17/Treg 之间的关系，为各种疾病（尤其是癌症）提供了新的预后和诊断生物标志物及有前途的治疗靶点。
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