Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran; Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Clin Nutr ESPEN. 2024 Apr;60:95-101. doi: 10.1016/j.clnesp.2024.01.012. Epub 2024 Jan 19.
BACKGROUND & AIMS: Rheumatoid arthritis is a systemic autoimmune disease that causes joint erosion, as well as damage to extra-articular organs. The aim of this study was the investigation of the association between the Mediterranean diet quality index with disease activity in patients with rheumatoid arthritis.
In this cross-sectional study 184 females with rheumatoid arthritis were studied in Kermanshah, Iran. The American College of Rheumatology's 2010 criteria were used to diagnose RA. The biochemical tests including erythrocyte sedimentation rate, C-reactive protein, rheumatoid facto, anti-nuclear antibody titration, antibodies against cyclic citrulline peptide, disease activity score 28 and the food frequency questionnaire was used to assess rheumatoid arthritis activity and the Mediterranean diet quality index, respectively. To compare the dietary intakes of participants across tertiles of Mediterranean diet score, we used Analysis of Variance. Multinomial logistic regression with three adjusted models was used to investigate the association between Mediterranean diet score with disease activity.
184 eligible patients with rheumatoid arthritis participated in this study. The mean age and duration of disease, body mass index, waist circumference and percent body fat did not differ significantly among the tertiles of the Mediterranean diet score (P-value>0.05). Participants in the highest tertile of Mediterranean diet score had significantly greater intakes of fruits, vegetables, fish, legume, nuts and had lowest intake of grains (refrain grain) and red and process meats to white meat ratio (P-value<0.05). There was no significant difference in terms of variables related to disease activity among the tertiles of the Mediterranean score (P-value>0.05). In multi-adjusted models, the odds ratio of Mediterranean diet scores no significant different in the third as compared to the first tertile of Mediterranean diet score (P-value>0.05).
Based on our findings there is no association between the Mediterranean diet score and disease activity of people with rheumatoid arthritis.
类风湿关节炎是一种系统性自身免疫性疾病，可导致关节侵蚀以及关节外器官损伤。本研究的目的是探讨地中海饮食质量指数与类风湿关节炎患者疾病活动度的关系。
本横断面研究纳入了伊朗克尔曼沙阿的 184 名女性类风湿关节炎患者。采用美国风湿病学会 2010 年标准诊断 RA。生化检测包括红细胞沉降率、C 反应蛋白、类风湿因子、抗核抗体滴度、环瓜氨酸肽抗体、28 疾病活动评分和食物频率问卷，分别用于评估类风湿关节炎活动度和地中海饮食质量指数。为了比较地中海饮食评分三分位组参与者的饮食摄入量，我们使用方差分析。采用多分类逻辑回归分析三个调整模型，以探讨地中海饮食评分与疾病活动之间的关系。
184 名符合条件的类风湿关节炎患者参与了本研究。地中海饮食评分三分位组之间的年龄、疾病持续时间、体重指数、腰围和体脂百分比无显著差异（P 值>0.05）。地中海饮食评分最高三分位组的参与者水果、蔬菜、鱼、豆类、坚果的摄入量显著增加，而谷物（限制谷物）、红肉和加工肉与白肉的比例最低（P 值<0.05）。地中海饮食评分三分位组之间与疾病活动相关的变量无显著差异（P 值>0.05）。在多调整模型中，与地中海饮食评分第一三分位组相比，第三三分位组的地中海饮食评分比值比无显著差异（P 值>0.05）。
根据我们的发现，地中海饮食评分与类风湿关节炎患者的疾病活动度之间没有关联。
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