Determination of the Relationship Between DNA Methylation Status of and Genes With Hypertension.

Hypertension is a multifactorial chronic disease due to the interaction of environmental factors with genetic alteration. and genes play an important role in the development of hypertension. Therefore, we analyzed the methylation status of and genes by using methylation-sensitive high-resolution melting (MSHRM) in a total of 78 hypertensive and 49 control subjects. In this study, we could not identify a significant association between and methylation and the hypertensive phenotype. Moreover, we could not find a direct association between and methylation and the fasting blood sugar, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, sodium (Na), creatinine (Cr), potassium (K), and urea levels in hypertensive patients. However, we found a significant difference between the methylated hypertensive patients and the unmethylated control subjects for potassium (K).