Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.
Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou, 310009, China.
Neurosci Bull. 2024 Jun;40(6):743-758. doi: 10.1007/s12264-024-01188-0. Epub 2024 Mar 14.
Parkinson's disease (PD) is one of the most common neurodegenerative diseases with a complex pathogenesis. Aggregations formed by abnormal deposition of alpha-synuclein (αSyn) lead to synapse dysfunction of the dopamine and non-dopamine systems. The loss of dopaminergic neurons and concomitant alterations in non-dopaminergic function in PD constitute its primary pathological manifestation. Positron emission tomography (PET), as a representative molecular imaging technique, enables the non-invasive visualization, characterization, and quantification of biological processes at cellular and molecular levels. Imaging synaptic function with PET would provide insights into the mechanisms underlying PD and facilitate the optimization of clinical management. In this review, we focus on the synaptic dysfunction associated with the αSyn pathology of PD, summarize various related targets and radiopharmaceuticals, and discuss applications and perspectives of PET imaging of synaptic dysfunction in PD.
帕金森病（PD）是最常见的神经退行性疾病之一，具有复杂的发病机制。异常沉积的α-突触核蛋白（αSyn）形成的聚集物导致多巴胺和非多巴胺系统的突触功能障碍。PD 的主要病理表现为多巴胺能神经元的丧失和非多巴胺能功能的改变。正电子发射断层扫描（PET）作为一种代表性的分子影像学技术，能够实现细胞和分子水平生物过程的非侵入性可视化、特征化和定量。使用 PET 成像突触功能将有助于深入了解 PD 的发病机制，并促进临床管理的优化。在本综述中，我们重点关注与 PD 的αSyn 病理学相关的突触功能障碍，总结了各种相关的靶点和放射性药物，并讨论了 PD 中突触功能障碍的 PET 成像的应用和前景。
