Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University School of Medicine, Bucheon, Korea.
Department of Statistics, Soonchunhyang University School of Medicine, Bucheon, Korea.
Clin Gastroenterol Hepatol. 2024 Sep;22(9):1953-1955.e1. doi: 10.1016/j.cgh.2024.02.028. Epub 2024 Mar 13.
Hepatocellular carcinoma (HCC) represents a significant global health burden, with its incidence and mortality rates varying significantly across different geographic regions. This variance is largely attributed to differences in the prevalence of risk factors such as hepatitis B and C infections, and alcohol consumption, as well as genetic predispositions that are distinct between Eastern and Western populations. Moreover, the impact of racial and ethnic diversity on the disease's epidemiology further complicates the global understanding and prediction of HCC. Such disparities highlight the critical need to evaluate the applicability of predictive models across diverse populations, acknowledging that a model developed in one region may not necessarily translate with the same accuracy or effectiveness when applied to another, because of these underlying epidemiologic and genetic differences. In this study, we aimed to assess the cross-regional applicability and accuracy of an HCC prediction model (Texas hepatocellular carcinoma risk index [THCC-RI] predictive model) originally developed in Western populations, within an Eastern context..
肝细胞癌（HCC）是一个全球性的健康负担，其发病率和死亡率在不同地理区域有很大差异。这种差异主要归因于乙型和丙型肝炎感染、饮酒等危险因素的流行率以及东西方人群之间明显的遗传易感性的差异。此外，种族和民族多样性对疾病的流行病学的影响进一步使全球对 HCC 的理解和预测变得复杂。这些差异突出表明，需要评估预测模型在不同人群中的适用性，认识到在一个地区开发的模型在应用于另一个地区时，由于存在这些潜在的流行病学和遗传差异，其准确性或有效性可能不一定相同。在本研究中，我们旨在评估一个 HCC 预测模型（德克萨斯肝细胞癌风险指数[THCC-RI]预测模型）在东方背景下的跨区域适用性和准确性，该模型最初是在西方人群中开发的。
