Wingard J R, Merz W G, Saral R
Ann Intern Med. 1979 Oct;91(4):539-43. doi: 10.7326/0003-4819-91-4-539.
Of 89 consecutive patients undergoing treatment for hematologic malignancies or undergoing allogeneic bone marrow transplantation, 60 were colonized with Candida albicans and 25 with C. tropicalis. However, of the 18 disseminated infections caused by Candida species, 15 infections in 14 patients were caused by C. tropicalis and only three infections in three patients by C. albicans. The setting in which the infection occurred, skin lesions, polyarthralgias, or polymyalgias, and the unexplained deterioration of renal function were features suggestive of the diagnosis. Defervescence occurred in 10 of the 14 treated patients with C. tropicalis infections in 1 to 6 d (mean, 2.5 d) after initiation of therapy, even though all continued to be granulocytopenic. Resolution occurred in eight of the 15 C. tropicalis infections. In one case outcome was indeterminate, four patients died due to the infection, and two died from other causes but with the infection unresolved.
在89例连续接受血液系统恶性肿瘤治疗或接受异基因骨髓移植的患者中，60例被白色念珠菌定植，25例被热带念珠菌定植。然而，在18例由念珠菌属引起的播散性感染中，14例患者的15次感染由热带念珠菌引起，只有3例患者的3次感染由白色念珠菌引起。感染发生的背景、皮肤病变、多关节痛或多肌痛以及无法解释的肾功能恶化是提示诊断的特征。14例接受治疗的热带念珠菌感染患者中，10例在开始治疗后1至6天（平均2.5天）退热，尽管所有患者仍处于粒细胞缺乏状态。15例热带念珠菌感染中有8例得到缓解。1例结局不确定，4例患者死于感染，2例死于其他原因但感染未得到解决。
