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在血小板单采术中，血小板因子 4 水平与供体年龄相关，并在储存过程中降低。

In platelet single donor apheresis, platelet factor 4 levels correlated with donor's age and decreased during storage.

机构信息

INSERM, U 1059 SAINBIOSE, Université Jean Monnet, Mines Saint-Étienne, 42023, Saint-Etienne, France.

Establissement Français du Sang Auvergne-Rhône-Alpes and INSERM U1059, 25 Boulevard Pasteur, 42100, Saint-Etienne, France.

出版信息

Sci Rep. 2024 Mar 14;14(1):6231. doi: 10.1038/s41598-024-56826-4.

DOI:10.1038/s41598-024-56826-4
PMID:38485973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10940288/
Abstract

The human population is ageing worldwide. The World Health Organization estimated that the world's population of people aged 60 years and older will increase to at least 30%, coinciding with a growing frequency of cognitive and cardiovascular disease. Recently, in preclinical studies platelet Factor 4 (PF4) was presented as a pro-cognitive factor. This molecule is released by platelets in the circulation and could be present in blood products destined for transfusion. We wondered if PF4 levels are correlated to the age of the blood donor or to the storage time of platelet concentrates (PCs) intended for transfusion? We observed higher levels of PF4 in PCs from elderly donors compared to younger donors, while PC storage time did not determine PF4 levels expression.

摘要

全球人口正在老龄化。世界卫生组织估计，全球 60 岁及以上人口将至少增加 30%，同时认知和心血管疾病的发病率也在不断上升。最近，在临床前研究中，血小板因子 4 (PF4) 被认为是一种认知促进因子。这种分子由循环中的血小板释放，可能存在于用于输血的血液制品中。我们想知道 PF4 水平是否与献血者的年龄或用于输血的血小板浓缩物 (PC) 的储存时间有关？我们观察到老年献血者的 PC 中的 PF4 水平高于年轻献血者，而 PC 的储存时间并不能决定 PF4 水平的表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def7/10940288/ef4e1acf7d33/41598_2024_56826_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def7/10940288/27161f2ec62c/41598_2024_56826_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def7/10940288/16fa87e8e760/41598_2024_56826_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def7/10940288/cd842ca8bc9d/41598_2024_56826_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def7/10940288/ef4e1acf7d33/41598_2024_56826_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def7/10940288/27161f2ec62c/41598_2024_56826_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def7/10940288/16fa87e8e760/41598_2024_56826_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def7/10940288/cd842ca8bc9d/41598_2024_56826_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/def7/10940288/ef4e1acf7d33/41598_2024_56826_Fig4_HTML.jpg

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本文引用的文献

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Platelet factors attenuate inflammation and rescue cognition in ageing.血小板因子可减轻炎症并改善衰老相关认知障碍。
Nature. 2023 Aug;620(7976):1071-1079. doi: 10.1038/s41586-023-06436-3. Epub 2023 Aug 16.
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Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice.血小板因子受长寿因子 klotho 诱导，并增强年轻和衰老小鼠的认知能力。
Nat Aging. 2023 Sep;3(9):1067-1078. doi: 10.1038/s43587-023-00468-0. Epub 2023 Aug 16.
4
Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice.血小板衍生趋化因子 CXCL4/血小板因子 4 可使海马神经发生年轻化，并恢复老年小鼠的认知功能。
Nat Commun. 2023 Aug 16;14(1):4375. doi: 10.1038/s41467-023-39873-9.
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Platelet factor 4 triggers thrombo-inflammation by bridging innate and adaptive immunity.血小板因子 4 通过桥接先天免疫和适应性免疫触发血栓炎症。
Int J Lab Hematol. 2023 Jun;45 Suppl 2:11-22. doi: 10.1111/ijlh.14075. Epub 2023 May 7.
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