Tynngård Nahreen, Boknäs Niklas, Trinks Marie, Dreimane Arta, Berlin Gösta
Research and Development Unit in Region Östergötland and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Department of Haematology and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Transfusion. 2019 Feb;59(2):723-728. doi: 10.1111/trf.15079. Epub 2018 Dec 12.
Storage of platelet concentrates (PCs) results in storage lesions with possible detrimental effects on platelet recovery after transfusion, which might affect their ability to prevent or arrest bleeding. The aim of this study was to compare the quality of PCs stored for 1 to 3 or 5 to 7 days by assessing the corrected count increment (CCI) after transfusion. To isolate the effects of storage time, we studied serial transfusions of PCs obtained from one donor and one donation, and transfused to one single recipient after storage for 1 to 3 days and 5 to 7 days.
Platelets were obtained from one donor by apheresis, divided into two units (>240 × 10 platelets/unit) and stored for 1 to 3 and 5 to 7 days, respectively, before transfusion. The PCs were transfused on normal indications to patients undergoing treatment at the hematology ward. Platelet count was measured before and after transfusion.
Thirty patients concluded the study according to the protocol. The mean storage time was 2.4 ± 0.7 and 5.7 ± 0.8 days for platelets transfused on Days 1 to 3 and 5 to 7, respectively. Storage for 5 to 7 days decreased the 1-hour transfusion response as compared to platelets stored 1 to 3 days, from a CCI of 17 ± 7 to 13 ± 5. Despite this decrease, 86% of the 5 to 7 days stored PCs resulted in a CCI above the cutoff value for a successful transfusion of 7.5, which was not significantly different to PCs stored for 1 to 3 days.
Storage of PCs for 5 to 7 days only slightly altered the transfusion response.
血小板浓缩物（PCs）的储存会导致储存损伤，可能对输血后血小板的恢复产生不利影响，这可能会影响其预防或止血的能力。本研究的目的是通过评估输血后的校正计数增加值（CCI）来比较储存1至3天或5至7天的PCs的质量。为了分离储存时间的影响，我们研究了从一名供体和一次捐献中获得的PCs的系列输血，并在储存1至3天和5至7天后输给一名单一受者。
通过单采从一名供体获得血小板，分成两个单位（>240×10⁹血小板/单位），分别储存1至3天和5至7天，然后进行输血。根据正常指征，将这些PCs输给血液科病房正在接受治疗的患者。在输血前后测量血小板计数。
30名患者按照方案完成了研究。在第1至3天和第5至7天输注的血小板的平均储存时间分别为2.4±0.7天和5.7±0.8天。与储存1至3天的血小板相比，储存5至7天降低了1小时的输血反应，CCI从17±7降至13±5。尽管有这种下降，但储存5至7天的PCs中有86%的CCI高于成功输血的临界值7.5，这与储存1至3天的PCs没有显著差异。
PCs储存5至7天仅轻微改变输血反应。
