Department of Anesthesiology, Changzhou Second People's Hospital, No.29, Xinglong Lane, Changzhou, 213003, China.
BMC Cardiovasc Disord. 2024 Mar 14;24(1):159. doi: 10.1186/s12872-024-03825-y.
The relationship between serum selenium (Se) and acute kidney injury after adult cardiac surgery (CSA-AKI) remains controversial. This study aimed to investigate the association of preoperative Se level with incident CSA-AKI.
A retrospective cohort study was conducted on patients who underwent cardiac surgery. The primary outcome was incident CSA-AKI. Multivariable logistic regression models and natural cubic splines were used to estimate the association of Se levels and primary outcome. A total of 453 patient with a mean age of 62.97 years were included. Among all patients, 159 (35.1%) incident cases of CSA-AKI were identified. The level of preoperative Se concentration in patients with CSA-AKI was significant lower than that in patients without CSA-AKI. The higher preoperative Se level was significantly associated with decreased risk of CSA-AKI (adjusted OR 0.91, 95% CI: 0.87-0.99). Dose-response relationship curve revealed a nearly L-shape correlation between serum Se selenium levels and incident CSA-AKI.
Our study suggested that a higher level of serum Se was significantly associated with lower risk of CSA-AKI. Further prospective studies are needed to clarify the causal relationship between serum Se level and incident CSA-AKI.
血清硒（Se）与成人心脏手术后急性肾损伤（CSA-AKI）之间的关系仍存在争议。本研究旨在探讨术前 Se 水平与 CSA-AKI 事件的相关性。
对接受心脏手术的患者进行回顾性队列研究。主要结局为 CSA-AKI 事件。多变量逻辑回归模型和自然三次样条用于估计 Se 水平与主要结局的相关性。共纳入 453 名平均年龄为 62.97 岁的患者。所有患者中，159 例（35.1%）发生 CSA-AKI 事件。CSA-AKI 患者的术前 Se 浓度水平明显低于无 CSA-AKI 患者。较高的术前 Se 水平与 CSA-AKI 风险降低显著相关（调整后的 OR 0.91，95%CI：0.87-0.99）。剂量-反应关系曲线显示血清 Se 水平与 CSA-AKI 事件之间呈近 L 形相关。
本研究表明，较高的血清 Se 水平与 CSA-AKI 风险降低显著相关。需要进一步的前瞻性研究来阐明血清 Se 水平与 CSA-AKI 事件之间的因果关系。
