Department of Pathology, First People's Hospital of Linping District, Hangzhou, Zhejiang, China.
Department of Pediatrics, Suzhou Hospital of Anhui Medical University, Suzhou, Anhui, China.
BMC Gastroenterol. 2024 Mar 14;24(1):108. doi: 10.1186/s12876-024-03194-y.
Pancreatic tumors in children are uncommon, and data is scarce. The purpose of this study is to examine the prognostic factors of pediatric pancreatic tumors in a population-based cohort.
The Surveillance, Epidemiology, and End Results (SEER) database was used to identify all pediatric patients with pancreatic tumors diagnosed between 1975 and 2018. The overall survival (OS) rates were determined using a Kaplan-Meier analysis. The log-rank test was used for univariate survival analysis. Cox proportional-hazards regression was used to determine the variables related to OS.
We identified 195 children with pancreatic tumors, with a median age at diagnosis of 16 years. Tumors were classified as neuroendocrine tumors (33.8%), solid pseudopapillary tumors (SPTs) (32.3%), pancreatoblastoma (11.3%), and others (22.6%). Of the patients, 30.3% had distant metastases, and 69.7% had surgery. Pancreatoblastomas were more common in younger children, whereas solid pseudopapillary tumors were more common in female patients. Overall 1-year, 3-year, and 5-year survival rates for all patients were 90.3%, 79.2%, and 77.7%, respectively. The Cox proportional hazard regression revealed that SEER stage and surgery were significant independent predictors of overall survival.
Pancreatic tumors are rare in children, and overall survival is grim except for SPTs. SEER stage and surgery were determined to be the most relevant determinants of OS in our study.
儿童胰腺肿瘤较为罕见，相关数据也较为缺乏。本研究旨在通过基于人群的队列研究，分析儿童胰腺肿瘤的预后因素。
本研究使用监测、流行病学和最终结果（SEER）数据库，确定了 1975 年至 2018 年间所有被诊断为胰腺肿瘤的儿科患者。采用 Kaplan-Meier 分析法确定总生存率（OS）。对数秩检验用于单变量生存分析。Cox 比例风险回归用于确定与 OS 相关的变量。
本研究共纳入了 195 名患有胰腺肿瘤的儿童患者，诊断时的中位年龄为 16 岁。肿瘤分类为神经内分泌肿瘤（33.8%）、实性假乳头状瘤（SPTs）（32.3%）、胰腺母细胞瘤（11.3%）和其他肿瘤（22.6%）。30.3%的患者发生远处转移，69.7%的患者接受了手术。胰腺母细胞瘤更常见于年幼的儿童，而 SPT 更常见于女性患者。所有患者的 1 年、3 年和 5 年总生存率分别为 90.3%、79.2%和 77.7%。Cox 比例风险回归显示，SEER 分期和手术是总体生存的显著独立预测因素。
儿童胰腺肿瘤较为罕见，除 SPT 外，总体生存率较差。SEER 分期和手术是本研究中 OS 最相关的决定因素。
