Department of Plastic Surgery, Hangzhou Children's Hospital, Hangzhou, China.
Department of Pediatric Surgery, Hangzhou Children's Hospital, Hangzhou, China.
Head Neck. 2024 Nov;46(11):2798-2805. doi: 10.1002/hed.27828. Epub 2024 May 25.
This study aims to analyze the clinicopathological characteristics and survival outcomes of tongue cancer in the pediatric population, a topic with limited existing data, using a population-based cohort.
Pediatric patients diagnosed with tongue cancer from 1975 to 2018 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Survival rates were assessed using Kaplan-Meier analysis. Univariate survival analysis was conducted with the log-rank test, while multivariate analysis involved Cox proportional-hazards regression to identify factors influencing overall survival (OS). A predictive nomogram was developed based on Cox regression findings.
In total, 97 pediatric patients with tongue cancer were identified, with a median age at diagnosis of 15 years (range: 1-19 years). Tumors were classified as squamous cell carcinoma (45.4%), rhabdomyosarcoma (RMS) (13.4%), and others (41.2%). Of the patients, squamous cell carcinoma was more common in older children, whereas rhabdomyosarcoma was more common in younger children. The Cox proportional hazard regression revealed that histology and surgery were significant independent predictors of overall survival. The chance of death increased with no surgery. Moreover, patients with squamous cell carcinoma or rhabdomyosarcoma have a poorer survival percentage than patients with other subtypes.
Tongue cancer in children is rare and associated with poor survival outcomes. This study highlights the significance of tumor histology and surgical intervention in determining overall survival, offering valuable insights for clinical decision-making in pediatric tongue cancer.
本研究旨在利用基于人群的队列分析儿童舌癌的临床病理特征和生存结局，这是一个数据有限的课题。
从监测、流行病学和最终结果（SEER）数据库中确定了 1975 年至 2018 年期间被诊断为舌癌的儿科患者。使用 Kaplan-Meier 分析评估生存率。单变量生存分析采用对数秩检验，多变量分析采用 Cox 比例风险回归来确定影响总生存率（OS）的因素。基于 Cox 回归结果制定了预测列线图。
共确定了 97 例患有舌癌的儿科患者，中位诊断年龄为 15 岁（范围：1-19 岁）。肿瘤分为鳞状细胞癌（45.4%）、横纹肌肉瘤（RMS）（13.4%）和其他（41.2%）。在这些患者中，大龄儿童中鳞状细胞癌更为常见，而横纹肌肉瘤则在较小的儿童中更为常见。Cox 比例风险回归显示，组织学和手术是总生存的独立显著预测因素。未手术的患者死亡几率增加。此外，患有鳞状细胞癌或横纹肌肉瘤的患者比患有其他亚型的患者的生存率百分比更低。
儿童舌癌罕见，且生存结局较差。本研究强调了肿瘤组织学和手术干预在确定总生存方面的重要性，为儿科舌癌的临床决策提供了有价值的见解。
