Kumar Shivendra, Sahu Kantrol Kumar, Agrawal Mohit, Singh Kuldeep, Saha Sunam
Department of Pharmacy, Rajiv Academy for Pharmacy, Mathura, India.
Institute of Pharmaceutical Research, GLA University, Mathura, UP 281406, India.
Curr Pharm Biotechnol. 2024 Mar 14. doi: 10.2174/0113892010276916240308082328.
Joints and arthritic conditions are among the most dangerous illnesses that humans have ever encountered and it is even more worrying that there is no recognized treatment for arthritis. The researchers looked for safer alternatives, such as herbal medicines, because the traditional treatments used to treat severe joint inflammatory issues have several negative side effects. A ligand-coated nanomedicine can bind to receptors that are overexpressed by cells in chronically inflammatory tissues, increasing its efficacy and reducing its systemic side effects. This is because the pathophysiology of rheumatoid arthritis suggests that macrophages and overexpressed molecules exist within inflamed tissues, which increases permeability and allows nanomedicines to accumulate in inflamed tissue and cause retention phenomena. The anti-arthritic properties of a variety of plants, their components, extracts, and phyto-isolates have been studied to date. These plant compounds can pose stability and delivery problems, which restricts their efficacy as a treatment for inflammatory diseases. The multifunctional and adaptable features of different nanoparticles can help herbal remedies based on nanotechnology get beyond the delivery constraints of different natural ingredients. The application of nanoformulations in tissue engineering is an additional strategy for delivering drugs directly to bone and cartilage in RA patients. The medication is more therapeutically effective due to nanoformulation's improved synovium and cartilage absorption, accumulation, and penetration at inflammatory joints. Herbal medications with a nanotechnology foundation exhibit superior pharmacokinetic and drug delivery qualities, aid in better oral absorption, regulate drug release, boost in vivo retention capacity, target delivery, and have synergistic effects. This review provides an update on the use of herbal medicines based on nanotechnology, which show promise in treating arthritis and other ailments.
关节和关节炎病症是人类所遇到的最危险的疾病之一，更令人担忧的是，目前尚无公认的关节炎治疗方法。研究人员在寻找更安全的替代方法，比如草药，因为用于治疗严重关节炎症问题的传统疗法有 several negative side effects。一种配体包被的纳米药物可以与慢性炎症组织中细胞过度表达的受体结合，提高其疗效并减少全身副作用。这是因为类风湿性关节炎的病理生理学表明，巨噬细胞和过度表达的分子存在于炎症组织中，这会增加通透性，使纳米药物在炎症组织中积累并产生滞留现象。迄今为止，人们已经研究了多种植物、其成分、提取物和植物分离物的抗关节炎特性。这些植物化合物可能存在稳定性和递送问题，这限制了它们作为炎症性疾病治疗方法的疗效。不同纳米颗粒的多功能性和适应性特征可以帮助基于纳米技术的草药克服不同天然成分的递送限制。纳米制剂在组织工程中的应用是将药物直接递送至类风湿性关节炎患者骨骼和软骨的另一种策略。由于纳米制剂改善了滑膜和软骨对炎症关节的吸收、积累和渗透，药物的治疗效果更佳。基于纳米技术的草药具有卓越的药代动力学和药物递送特性，有助于更好的口服吸收、调节药物释放、提高体内滞留能力、实现靶向递送并具有协同效应。本综述提供了基于纳米技术的草药使用的最新情况，这些草药在治疗关节炎和其他疾病方面显示出前景。
