Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park-2, Greater Noida, Uttar Pradesh, 201306, India.
Noida Institute of Engineering and Technology, 19 Knowledge Park-2, Greater Noida, Uttar Pradesh, 201306, India.
Curr Drug Targets. 2024;25(10):700-714. doi: 10.2174/0113894501306516240531053653.
Arthritis, a prevalent inflammatory joint condition, presents challenges for effective therapeutic interventions, with conventional treatments often limited in efficacy and associated with adverse effects. Recent years have witnessed a growing interest in exploring natural compounds, particularly phytoconstituents, renowned for their anti-inflammatory and joint-protective properties. This review aims to illuminate the potential of employing nanotherapeutic approaches with phytoconstituents for enhanced arthritis management. The integration of nanotechnology with phytoconstituents emerges as a promising strategy, addressing limitations in traditional arthritis treatments. Nanocarriers like liposomes and nanoparticles provide a platform for targeted drug delivery, improving the bioavailability of phytoconstituents. Furthermore, the combined effects of phytoconstituents can be leveraged to target multiple pathways in arthritis pathogenesis, including inflammation, oxidative stress, and cartilage degradation. Key phytoconstituents, such as curcumin, resveratrol, and quercetin, exhibit anti-inflammatory and immunomodulatory properties. Nevertheless, their therapeutic potential is often impeded by challenges like poor solubility, stability, and bioavailability. Nanocarriers offer solutions by enhancing pharmacokinetics and enabling sustained release, thereby boosting overall therapeutic efficacy. The review explores the mechanisms underlying the anti-arthritic effects of phytoconstituents and their nanoformulations, including the modulation of pro-inflammatory cytokines, inhibition of matrix metalloproteinases, and reduction of oxidative stress. In summary, the integration of phytoconstituents with nanotechnology presents a promising avenue for developing targeted and effective arthritis therapies. This comprehensive review serves as a valuable resource for researchers, clinicians, and pharmaceutical developers seeking innovative approaches to address the intricate challenges associated with arthritis management.
关节炎是一种常见的炎症性关节疾病，给有效的治疗干预带来了挑战，传统的治疗方法往往疗效有限，并伴有不良反应。近年来，人们越来越关注探索天然化合物，特别是具有抗炎和关节保护特性的植物成分。本综述旨在阐明采用植物成分的纳米治疗方法在增强关节炎管理方面的潜力。将纳米技术与植物成分结合起来是一种很有前途的策略，可以解决传统关节炎治疗方法的局限性。脂质体和纳米粒子等纳米载体为药物靶向递送提供了平台，提高了植物成分的生物利用度。此外，植物成分的联合作用可以针对关节炎发病机制中的多个途径，包括炎症、氧化应激和软骨降解。姜黄素、白藜芦醇和槲皮素等关键植物成分具有抗炎和免疫调节特性。然而，它们的治疗潜力常常受到溶解度、稳定性和生物利用度等挑战的限制。纳米载体通过增强药代动力学和实现持续释放来解决这些问题，从而提高整体治疗效果。本综述探讨了植物成分及其纳米制剂的抗关节炎作用机制，包括对促炎细胞因子的调节、基质金属蛋白酶的抑制和氧化应激的减轻。总之，将植物成分与纳米技术相结合为开发针对关节炎的靶向和有效治疗方法提供了有前途的途径。本综述为研究人员、临床医生和药物开发人员提供了有价值的资源，为解决关节炎管理中复杂的挑战寻求创新方法。
