Xiao Qing-Ao, Qin Lei, Yu Jing, Hu Yin-Tao, Ai Lin-Feng, Wang De-Cheng, Xia Xuan, Zhang Xiao-Lin
Department of Interventional Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.
Department of Interventional Radiology, Yichang Central People's Hospital, Yichang, Hubei, China.
Front Microbiol. 2024 Feb 29;15:1329521. doi: 10.3389/fmicb.2024.1329521. eCollection 2024.
Numerous investigations have underscored the causal effect between chronic pain (CP) and gut microbiota, jointly contributing to the onset and development of widespread CP. Nonetheless, there was still uncertainty about the causal effect between gut microbiota and chronic regional pain (CRP).
Genome-wide association study (GWAS) summary data of gut microbial taxa (MiBioGen Consortium: 211 microbiotas and the Dutch Microbiome Project: 207 microbiotas) and eight types of CRP were used to reveal the causal effect between persistent pain in a specific region of the body and gut microbiota. A two-sample bidirectional Mendelian randomization (MR) design was used. In order to ensure the accuracy of the results, multiple sensitivity analyses were employed.
This study uncovered significant causal associations between six gut microbial taxa and three types of CRP (forward: for general pain; , and for back pain. Reverse: knee pain for and ) by forward and reverse MR analysis. These findings had been verified by a rigorous Bonferroni correction. Furthermore, this research identified 19 microbial taxa that exhibited potential correlations with four types of CRP. There are no significant or potential gut microbiotas that were associated with other types of CRP, including fascial pain, stomach or abdominal pain, and hip pain.
This two-sample bidirectional MR analysis unveiled the causality between gut microbial taxa and eight CRP conditions. The findings reveal the interplay between CRP and 6 gut microbiotas while also delineating 19 potential specific microbial taxa corresponding to diverse locations of persistent pain.
大量研究强调了慢性疼痛（CP）与肠道微生物群之间的因果关系，它们共同促成了广泛慢性疼痛的发生和发展。然而，肠道微生物群与慢性局部疼痛（CRP）之间的因果关系仍存在不确定性。
利用肠道微生物分类群的全基因组关联研究（GWAS）汇总数据（微生物组生物银行联盟：211个微生物群和荷兰微生物组计划：207个微生物群）以及八种类型的CRP，以揭示身体特定区域的持续性疼痛与肠道微生物群之间的因果关系。采用双样本双向孟德尔随机化（MR）设计。为确保结果的准确性，进行了多项敏感性分析。
本研究通过正向和反向MR分析发现，六种肠道微生物分类群与三种类型的CRP之间存在显著的因果关联（正向： 与一般疼痛相关； 、 和 与背痛相关。反向： 与膝盖疼痛相关）。这些发现经过了严格的Bonferroni校正验证。此外，本研究确定了19种微生物分类群与四种类型的CRP存在潜在相关性。没有发现与其他类型的CRP（包括筋膜疼痛、胃痛或腹痛以及髋部疼痛）相关的显著或潜在肠道微生物群。
这种双样本双向MR分析揭示了肠道微生物分类群与八种CRP状况之间的因果关系。研究结果揭示了CRP与6种肠道微生物群之间的相互作用，同时还确定了19种潜在的特定微生物分类群，它们对应于持续性疼痛的不同部位。
