Karmon G, Savir H, Zevin D, Levi J
Ann Ophthalmol. 1979 Jul;11(7):1013-7.
The case of a 40-year-old patient who underwent an unsuccessful cadaver kidney transplantation and was treated with ethambutol and isoniazid is reported. A bilateral retrobulbar neuropathy with an unusual central bitemporal hemianopic scotoma was found. Ethambutol was stopped and only small improvement of the visual acuity followed. Isoniazid was discontinued later, followed by a dramatic improvement in the visual acuity. The hazards of optic nerve toxicity due to ethambutol are known. We emphasize the potential danger in the use of ethambutol and isoniazid.
报告了一名40岁患者的病例，该患者接受尸体肾移植未成功，随后接受乙胺丁醇和异烟肼治疗。发现其患有双侧球后视神经炎，并伴有不寻常的中央双颞侧偏盲性暗点。停用乙胺丁醇后，视力仅有轻微改善。随后停用异烟肼，视力显著改善。乙胺丁醇导致视神经毒性的危害是已知的。我们强调使用乙胺丁醇和异烟肼的潜在危险。
