Department of First Clinical Medicine, Shanxi Medical University, Taiyuan, China.
Department of Breast Surgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Front Immunol. 2024 Feb 29;15:1368687. doi: 10.3389/fimmu.2024.1368687. eCollection 2024.
At present, the incidence rate of breast cancer ranks first among new-onset malignant tumors in women. The tumor microenvironment is a hot topic in tumor research. There are abundant cells in the tumor microenvironment that play a protumor or antitumor role in breast cancer. During the treatment of breast cancer, different cells have different influences on the therapeutic response. And after treatment, the cellular composition in the tumor microenvironment will change too. In this review, we summarize the interactions between different cell compositions (such as immune cells, fibroblasts, endothelial cells, and adipocytes) in the tumor microenvironment and the treatment mechanism of breast cancer. We believe that detecting the cellular composition of the tumor microenvironment is able to predict the therapeutic efficacy of treatments for breast cancer and benefit to combination administration of breast cancer.
目前，乳腺癌的发病率在女性新发恶性肿瘤中位居首位。肿瘤微环境是肿瘤研究的热点。肿瘤微环境中存在丰富的细胞，这些细胞在乳腺癌中发挥着促肿瘤或抗肿瘤的作用。在乳腺癌的治疗过程中，不同的细胞对治疗反应有不同的影响。并且在治疗后，肿瘤微环境中的细胞组成也会发生变化。在这篇综述中，我们总结了肿瘤微环境中不同细胞成分（如免疫细胞、成纤维细胞、内皮细胞和脂肪细胞）之间的相互作用以及乳腺癌的治疗机制。我们相信，检测肿瘤微环境中的细胞组成能够预测乳腺癌治疗的疗效，并有助于乳腺癌的联合治疗。
