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社会经济差异与神经退行性疾病死亡率:一项针对 65 岁及以上比利时男女的基于人群的研究。

Socioeconomic Disparities in Neurodegenerative Disease Mortality: A Population-Based Study among Belgian Men and Women Aged 65 or Older.

机构信息

Brussels Institute for Social and Population Studies/Vrije Universiteit Brussel, Brussels, Belgium.

出版信息

Inquiry. 2024 Jan-Dec;61:469580241237113. doi: 10.1177/00469580241237113.

Abstract

This study investigates the association between socioeconomic position (SEP) - in terms of income and education - and mortality from neurodegenerative diseases, that is, dementia, parkinsonism, and motor neuron diseases (MNDs). We calculated age-standardized mortality rates and mortality rate ratios using log linear Poisson regression for different SEP groups, stratified by gender, age-group, and care home residency, utilizing the 2011 Belgian census linked to register data on cause-specific mortality for 2011 to 2016. Mortality was significantly higher in the lowest educational- and income groups. The largest disparities were found in dementia mortality. Income had a strong negative effect on parkinsonism mortality, education a positive effect. We found no significant association between SEP and MND. Our study provides evidence supporting the presence of socioeconomic disparities in mortality due to neurodegeneration. We found a strong negative association between SEP and NDD mortality, which varies between NDD, gender and care home residency.

摘要

本研究调查了社会经济地位(SEP)——以收入和教育程度衡量——与神经退行性疾病(包括痴呆、帕金森病和运动神经元病)死亡率之间的关联。我们使用对数线性泊松回归计算了不同 SEP 组的年龄标准化死亡率和死亡率比,按性别、年龄组和养老院居住情况进行分层,利用 2011 年比利时人口普查与 2011 年至 2016 年特定原因死亡率登记数据进行关联。结果发现,受教育程度和收入最低的群体死亡率显著更高。痴呆症死亡率的差异最大。收入对帕金森病死亡率有很强的负面影响,而教育程度则有积极影响。我们没有发现 SEP 与 MND 之间存在显著关联。本研究提供了证据支持神经退行性疾病导致的死亡率存在社会经济差异。我们发现 SEP 与 NDD 死亡率之间存在强烈的负相关,这种关联在 NDD、性别和养老院居住情况之间存在差异。

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Ageing as a risk factor for neurodegenerative disease.衰老作为神经退行性疾病的一个风险因素。
Nat Rev Neurol. 2019 Oct;15(10):565-581. doi: 10.1038/s41582-019-0244-7. Epub 2019 Sep 9.

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