King George's Medical University, Lucknow, India.
Head Neck Pathol. 2024 Mar 15;18(1):18. doi: 10.1007/s12105-024-01611-y.
Only limited cases have been reported about the clear cell variant of squamous cell carcinoma occurring in the oral cavity. The present study regards the case showing the histopathological features of both the clear cell and acantholytic variants of oral squamous cell carcinoma. A review of the literature has been done to understand the pathogenesis of those changes. Also, a hypothesis has been given that the clear cell changes could be the consequences of the cascades of the acantholytic process and not a separate entity. Therefore, more research is required to confirm this hypothesis and understand the prognosis of the lesion.
仅有少数关于口腔鳞状细胞癌透明细胞变异型的病例报告。本研究报告了一例同时具有透明细胞和棘层松解变异型口腔鳞状细胞癌组织病理学特征的病例。对文献进行了复习，以了解这些变化的发病机制。此外，还提出了一个假设，即透明细胞变化可能是棘层松解过程的级联反应的结果，而不是一个独立的实体。因此，需要进一步的研究来证实这一假设，并了解病变的预后。
