Mroueh Rayan, Nevala Aapeli, Haapaniemi Aaro, Pitkäniemi Janne, Salo Tuula, Mäkitie Antti A
Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland.
Finnish Cancer Registry, Helsinki, Finland.
Head Neck. 2020 Aug;42(8):1848-1858. doi: 10.1002/hed.26107. Epub 2020 Feb 14.
The incidence and survival of oral squamous cell carcinoma (OSCC) patients have increased in recent years. Understanding their long-term survival aspects is essential for optimal treatment and follow-up planning. Almost one in five cancers diagnosed occurs nowadays in individuals with a previous diagnosis of cancer.
Patients diagnosed with primary OSCC during 1953-2015 were retrieved from the Finnish Cancer Registry. Both standardized incidence ratios (SIR) and excess absolute risk (EAR) per 1000 person-years at risk (PYR) of second primary cancer (SPC) were calculated relative to the general population.
Among 6602 first primary OSCC patients there were 640 (10%) SPCs. The SIR for SPCs was 1.85 (95% CI: 1.71-1.99, P < .001) corresponding to an EAR of 8.78 (95% CI: 7.29-10.26).
Health care professionals should be aware of the second primary cancer risk after management of primary OSCC and patients need to be counseled about this phenomenon.
近年来，口腔鳞状细胞癌（OSCC）患者的发病率和生存率有所上升。了解其长期生存情况对于优化治疗和后续随访计划至关重要。如今，几乎每五例确诊癌症的患者中就有一例曾被诊断患有癌症。
从芬兰癌症登记处检索出1953年至2015年期间被诊断为原发性OSCC的患者。计算相对于普通人群的标准化发病率（SIR）和每1000人年风险（PYR）的第二原发性癌症（SPC）的超额绝对风险（EAR）。
在6602例首次原发性OSCC患者中，有640例（10%）发生了SPC。SPC的SIR为1.85（95%CI：1.71 - 1.99，P <.001），对应的EAR为8.78（95%CI：7.29 - 10.26）。
医疗保健专业人员应意识到原发性OSCC治疗后发生第二原发性癌症的风险，并且需要就这一现象向患者提供咨询。
