State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, China.
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730000, China.
Antiviral Res. 2024 May;225:105868. doi: 10.1016/j.antiviral.2024.105868. Epub 2024 Mar 13.
Porcine Reproductive and Respiratory Syndrome (PRRS) presents a formidable viral challenge in swine husbandry. Confronting the constraints of existing veterinary pharmaceuticals and vaccines, this investigation centers on Caffeic Acid Phenethyl Ester (CAPE) as a prospective clinical suppressant for the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The study adopts an integrated methodology to evaluate CAPE's antiviral attributes. This encompasses a dual-phase analysis of CAPE's interaction with PRRSV, both in vitro and in vivo, and an examination of its influence on viral replication. Varied dosages of CAPE were subjected to empirical testing in animal models to quantify its efficacy in combating PRRSV infections. The findings reveal a pronounced antiviral potency, notably in prophylactic scenarios. As a predominant component of propolis, CAPE stands out as a promising candidate for clinical suppression, showing exceptional effectiveness in pre-exposure prophylaxis regimes. This highlights the potential of CAPE in spearheading cutting-edge strategies for the management of future PRRSV outbreaks.
猪繁殖与呼吸综合征（PRRS）是养猪业面临的一项严峻的病毒性挑战。本研究针对现有的兽医药物和疫苗的局限性，将咖啡酸苯乙酯（CAPE）作为猪繁殖与呼吸综合征病毒（PRRSV）的一种有前途的临床抑制剂。该研究采用综合方法评估 CAPE 的抗病毒特性。这包括 CAPE 与 PRRSV 在体外和体内相互作用的双相分析，以及对其病毒复制影响的研究。不同剂量的 CAPE 在动物模型中进行了实证测试，以量化其对抗 PRRSV 感染的功效。研究结果表明，CAPE 具有明显的抗病毒活性，特别是在预防情况下。CAPE 作为蜂胶的主要成分之一，作为临床抑制的候选药物具有很大的潜力，在暴露前预防方案中表现出卓越的效果。这突出了 CAPE 在为未来 PRRSV 爆发管理提供前沿策略方面的潜力。
