Chongqing Key Laboratory of Oral Disease and Biomedical Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Stomatological Hospital of Chongqing Medical University, Chongqing, 401174, P. R. China.
The People's Hospital of Kaizhou District, Chongqing, 405499, P. R. China.
Adv Mater. 2024 Jun;36(25):e2309774. doi: 10.1002/adma.202309774. Epub 2024 Mar 28.
Tissue adhesives are promising alternatives to sutures and staples to achieve wound closure and hemostasis. However, they often do not work well on tissues that are soaked in blood or other biological fluids, and organs that are typically exposed to a variety of harsh environments such as different pH values, nonhomogeneous distortions, continuous expansions and contractions, or high pressures. In this study, a nature-derived multilayered hetero-bioadhesive patch (skin secretion of Andrias davidianus (SSAD)-Patch) based on hydrophilic/hydrophobic pro-healing bioadhesives derived from the SSAD is developed, which is designed to form pressure-triggered strong adhesion with wet tissues. The SSAD-Patch is successfully applied for the sealing and healing of tissue defects within 10 s in diverse extreme injury scenarios in vivo including rat stomach perforation, small intestine perforation, fetal membrane defect, porcine carotid artery incision, and lung lobe laceration. The findings reveal a promising new type of self-adhesive regenerative SSAD-Patch, which is potentially adaptable to broad applications (under different pH values and air or liquid pressures) in sutureless wound sealing and healing.
组织粘合剂是缝合线和订书钉的有前途的替代品，可以实现伤口闭合和止血。然而，它们在被血液或其他生物液体浸湿的组织上通常效果不佳，而且器官通常暴露于各种恶劣环境中，例如不同的 pH 值、不均匀的变形、持续的膨胀和收缩或高压。在这项研究中，开发了一种基于来源于 AD 皮肤分泌物（SSAD）的亲水性/疏水性促愈合生物粘合剂的天然多层异性生物粘合剂贴片（AD 皮肤分泌物贴片，SSAD-Patch），旨在与湿组织形成压力触发的强粘附。SSAD-Patch 成功地应用于在体内的各种极端损伤情况下的组织缺陷的密封和愈合，包括大鼠胃穿孔、小肠穿孔、胎膜缺陷、猪颈动脉切口和肺叶撕裂，时间在 10 秒内。这些发现揭示了一种有前途的新型自粘性再生 SSAD-Patch，它有可能适应广泛的应用（在不同的 pH 值和空气或液体压力下），无需缝合即可进行伤口密封和愈合。
