Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Asadabad School of Medical Sciences, Asadabad, Iran.
Endocrinol Diabetes Metab. 2024 Mar;7(2):e00477. doi: 10.1002/edm2.477.
Little is known about how polycystic ovary syndrome (PCOS) is linked to irritable bowel syndrome (IBS). This study aimed to review the existing literature regarding the association between PCOS or its symptoms and complications with IBS.
In this review, studies that investigated the proposed cross-link between features of PCOS and IBS were included. This review collectively focused on recent findings on the mechanism and novel insight regarding the association between IBS and PCOS in future clinical practice. An electronic search of PubMed, Scopus, Epistemonikos, Cochrane Library and Google Scholar was performed. We did not restrict the study setting and publication date.
The existing evidence has not completely answered the question of whether there is an association between PCOS and IBS and vice versa. Six case-control studies (793 women with PCOS and 547 women in the control group) directly assessed the association between PCOS and IBS. The prevalence of IBS among women with PCOS in these studies has ranged from 10% to 52% compared with 5%-50% in control groups. Evidence suggested the common pathways may have contributed to the interaction between IBS and PCOS, including metabolic syndrome, sex hormone fluctuation, dysregulation of neurotransmitters, psychological problems and environmental and lifestyle factors. To date, it is still ambiguous which of the mentioned components largely contributes to the pathogenesis of both.
Although limited evidence has shown a higher prevalence of IBS in women with PCOS, there are several potential, direct and common indirect pathways contributing to the development of both IBS and PCOS.
关于多囊卵巢综合征（PCOS）与肠易激综合征（IBS）之间的关联知之甚少。本研究旨在综述现有文献中关于 PCOS 或其症状和并发症与 IBS 之间关联的研究。
在本次综述中，纳入了研究 PCOS 特征与 IBS 之间潜在关联的研究。本综述主要关注最近关于 IBS 和 PCOS 之间关联的机制和新见解，以便为未来的临床实践提供参考。对 PubMed、Scopus、Epistemonikos、Cochrane 图书馆和 Google Scholar 进行了电子检索。我们未对研究设置和发表日期进行限制。
现有的证据尚未完全回答 PCOS 和 IBS 之间是否存在关联以及反之亦然的问题。六项病例对照研究（793 名患有 PCOS 的女性和 547 名对照组女性）直接评估了 PCOS 和 IBS 之间的关联。这些研究中患有 PCOS 的女性中 IBS 的患病率范围为 10%至 52%，而对照组中为 5%至 50%。有证据表明，共同的途径可能促成了 IBS 和 PCOS 之间的相互作用，包括代谢综合征、性激素波动、神经递质失调、心理问题以及环境和生活方式因素。迄今为止，仍不清楚上述哪些因素在很大程度上导致了这两种疾病的发病机制。
尽管有限的证据表明患有 PCOS 的女性中 IBS 的患病率较高，但有几个潜在的、直接的和共同的间接途径促成了 IBS 和 PCOS 的发生。
