Srnovršnik Tinkara, Virant-Klun Irma, Pinter Bojana
Division for Women's Healthcare, Šiška Unit, Community Health Centre Ljubljana, Metelkova ulica 9, 1000 Ljubljana, Slovenia.
Faculty of Medicine, University of Ljubljana, Vrazov Trg 2, 1000 Ljubljana, Slovenia.
Life (Basel). 2023 Jan 4;13(1):138. doi: 10.3390/life13010138.
Exposure to endocrine disrupting chemicals (EDCs) can result in alterations of the female reproductive system, including polycystic ovary syndrome (PCOS). The aim of this review was to summarize the knowledge about the association of EDCs (bisphenols, parabens, and triclosan) with PCOS. We conducted an electronic literature search using PubMed for studies published between January 2007 and October 2022 on EDCs related to PCOS, and evaluated the association of PCOS with bisphenols, parabens and triclosan in 15 articles. Most studies revealed significantly higher plasma, urinary or follicular fluid levels of bisphenol A (BPA) in women with PCOS, and some showed a positive correlation of BPA with insulin resistance, polycystic morphology on ultrasound, hepatic steatosis, bilirubin levels, as well as free androgen index, androstenedione and testosterone serum levels, and markers of low-grade chronic inflammation. There was a negative correlation of BPA with markers of ovarian reserve, sex hormone binding globulin and vitamin D-binding protein. Parabens and triclosan have been studied in only one study each, with no significant associations with PCOS observed. Our review revealed an association of BPA with PCOS and negative effects of BPA on human ovaries; more research is needed to assess the potential associations of parabens and triclosan with PCOS.
接触内分泌干扰化学物质（EDCs）会导致女性生殖系统发生改变，包括多囊卵巢综合征（PCOS）。本综述的目的是总结有关EDCs（双酚类、对羟基苯甲酸酯类和三氯生）与PCOS关联的知识。我们使用PubMed对2007年1月至2022年10月发表的关于与PCOS相关的EDCs的研究进行了电子文献检索，并在15篇文章中评估了PCOS与双酚类、对羟基苯甲酸酯类和三氯生的关联。大多数研究表明，PCOS女性的血浆、尿液或卵泡液中双酚A（BPA）水平显著更高，一些研究显示BPA与胰岛素抵抗、超声下的多囊形态、肝脂肪变性、胆红素水平以及游离雄激素指数、雄烯二酮和睾酮血清水平以及低度慢性炎症标志物呈正相关。BPA与卵巢储备标志物、性激素结合球蛋白和维生素D结合蛋白呈负相关。对羟基苯甲酸酯类和三氯生仅各有一项研究，未观察到与PCOS有显著关联。我们的综述揭示了BPA与PCOS的关联以及BPA对人类卵巢的负面影响；需要更多研究来评估对羟基苯甲酸酯类和三氯生与PCOS之间的潜在关联。
