用于评估早产儿脑血流动力学的多波长多距离扩散相关光谱系统。

Otic Nikola, Sunwoo John, Huang Yujing, Martin Alyssa, Robinson Mitchell B, Zimmermann Bernhard, Carp Stefan, Inder Terrie, El-Dib Mohamed, Franceschini Maria Angela, Renna Marco

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

Neurophotonics Center, Boston University, Boston, Massachusetts, USA.

Biomed Opt Express. 2024 Feb 29;15(3):1959-1975. doi: 10.1364/BOE.505783. eCollection 2024 Mar 1.

Infants born at an extremely low gestational age (ELGA, < 29 weeks) are at an increased risk of intraventricular hemorrhage (IVH), and there is a need for standalone, safe, easy-to-use tools for monitoring cerebral hemodynamics. We have built a multi-wavelength multi-distance diffuse correlation spectroscopy device (MW-MD-DCS), which utilizes time-multiplexed, long-coherence lasers at 785, 808, and 853 nm, to simultaneously quantify the index of cerebral blood flow (CBF) and the hemoglobin oxygen saturation (SO). We show characterization data on liquid phantoms and demonstrate the system performance on the forearm of healthy adults, as well as clinical data obtained on two preterm infants.

孕周极低（ELGA，<29周）出生的婴儿发生脑室内出血（IVH）的风险增加，因此需要独立、安全且易于使用的工具来监测脑血流动力学。我们构建了一种多波长多距离扩散相关光谱装置（MW-MD-DCS），该装置利用785、808和853 nm的时分复用、长相干激光器，同时量化脑血流量（CBF）指标和血红蛋白氧饱和度（SO）。我们展示了液体模型的表征数据，并证明了该系统在健康成年人前臂上的性能，以及在两名早产儿身上获得的临床数据。